1-Boc-4-methylpiperidine-4-carboxylic acid

1-Boc-4-methylpiperidine-4-carboxylic acid Suppliers list

Company Name:	Wuhan Chemwish Technology Co., Ltd
Tel:	86-027-67849912
Email:	sales@chemwish.com

1-Boc-4-methylpiperidine-4-carboxylic acid manufacturers

1-Boc-4-methylpiperidine-4-carboxylic acid Basic information

Product Name:	1-Boc-4-methylpiperidine-4-carboxylic acid
Synonyms:	N-BOC-4-METHYL ISONIPECOTIC ACID;N-BOC-4-METHYL-4-METHYLPIPERIDINECARBOXYLIC ACID;N-BOC-4-METHYL-4-PIPERIDINECARBOXYLIC ACID;CHEMBRDG-BB 4002933;4-METHYL-4-CARBOXY-1-N-BOC-PIPERIDINE;4-METHYL-PIPERIDINE-1,4-DICARBOXYLIC ACID MONO-TERT-BUTYL ESTER;1-BOC-4-METHYL-PIPERIDINE-4-CARBOXYLIC ACID;1-Boc-4-methyl-4-piperidinecarboxylic Acid
CAS:	189321-63-9
MF:	C12H21NO4
MW:	243.3
EINECS:
Product Categories:	API intermediates;Amino Acids and Derivatives;Heterocycles;Pyridines
Mol File:	189321-63-9.mol

1-Boc-4-methylpiperidine-4-carboxylic acid Chemical Properties

Boiling point	354.3±35.0 °C(Predicted)
density	1.129±0.06 g/cm3(Predicted)
storage temp.	2-8°C
pka	4.69±0.20(Predicted)
Appearance	White to off-white Solid
InChI	InChI=1S/C12H21NO4/c1-11(2,3)17-10(16)13-7-5-12(4,6-8-13)9(14)15/h5-8H2,1-4H3,(H,14,15)
InChIKey	OKBNEDPOUYRYNP-UHFFFAOYSA-N
SMILES	N1(C(OC(C)(C)C)=O)CCC(C)(C(O)=O)CC1
CAS DataBase Reference	189321-63-9(CAS DataBase Reference)

Safety Information

MSDS Information

1-Boc-4-methylpiperidine-4-carboxylic acid Usage And Synthesis

Chemical Properties	White to Light yellow powder to crystal
Synthesis	A mixture of Ethyl N-Boc-4-methylpiperidine-4-carboxylate (4.1 g, 15.1mmol) and lithium hydroxide (2.17g, 90.6mmol) in methanol (3OmL)ZH2O (2OmL) was stirred at a temperature of about 25 ℃ for 16h. After evaporation to dryness, the residue was partitioned between DCM and brine. The organic layer was separated, dried (MgSO4), filtered, and concentrated under reduced pressure to provide 3.38g of 1-Boc-4-methylpiperidine-4-carboxylic acid as a white solid (yield 92.0 percent).
References	[1] Patent: WO2008/89201, 2008, A2. Location in patent: Page/Page column 234 [2] Patent: US2010/137305, 2010, A1. Location in patent: Page/Page column 36 [3] Bioorganic and Medicinal Chemistry Letters, 2004, vol. 14, # 14, p. 3675 - 3678 [4] Patent: US6083949, 2000, A [5] Patent: EP854870, 2009, B1. Location in patent: Page/Page column 42

1-Boc-4-methylpiperidine-4-carboxylic acid Preparation Products And Raw materials

Raw materials

Tag:1-Boc-4-methylpiperidine-4-carboxylic acid(189321-63-9) Related Product Information

o-Toluic acid p-Toluic acid Triacetonediamine tert-Butyl carbazate 1,2,2,6,6-Pentamethyl-4-piperidinol Isonipecotic acid 2,2,6,6-Tetramethyl-4-piperidinol N-Boc-3-Methylnipecotic acid ethyl ester Ethyl N-Boc-4-methylpiperidine-4-carboxylate 1-N-Boc-3-Methylpiperidine-3-carboxylic acid Boc-4-phenylpiperidine-4-carboxylic acid 1-Boc-4-ethyl-4-piperidinecarboxylic acid N-BOC-4-(P-FLUOROPHENYL)-4-PIPERIDINECARBOXYLIC ACID 1,4-Piperidinedicarboxylic acid, 4-(2-propen-1-yl)-, 1-(1,1-dimethylethyl) ester N-BOC-4-BENZYL-4-PIPERIDINECARBOXYLIC ACID METHYL 4-AMINOMETHYL-1-BOC-PIPERIDINE-4-CARBOXYLATE N-Boc-4-(p-chlorophenyl)-4-piperidine carboxylic acid Boc-4-cyclohexyl-piperidine-4-carboxylic acid