Ethyl 5-bromothiophene-3-carboxylate manufacturers
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| | Ethyl 5-bromothiophene-3-carboxylate Basic information |
| Product Name: | Ethyl 5-bromothiophene-3-carboxylate | | Synonyms: | Ethyl 5-bromothiophene-3-carboxylate;5-BroMo-thiophene-3-carboxylic acid ethyl ester;5-Bromothiophene-3-carboxylic acid ethyl ester, >=98%;5-bromo-3-Thiophenecarboxylic acid ethyl ester;PI-35048 ethyl 5-bromothiophene-3-carboxylate;Ethyl 5-bromothiophene-3-carboxylate 97+%;3-Thiophenecarboxylic acid, 5-bromo-, ethyl ester;Ethyl 5-bromothiophene-4-carboxylate | | CAS: | 170355-38-1 | | MF: | C7H7BrO2S | | MW: | 235.1 | | EINECS: | | | Product Categories: | | | Mol File: | 170355-38-1.mol |  |
| | Ethyl 5-bromothiophene-3-carboxylate Chemical Properties |
| Boiling point | 65-66 °C | | density | 1.572±0.06 g/cm3(Predicted) | | storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C | | form | liquid | | color | Colourless to yellow | | InChI | InChI=1S/C7H7BrO2S/c1-2-10-7(9)5-3-6(8)11-4-5/h3-4H,2H2,1H3 | | InChIKey | LUYMKCLOYODOEI-UHFFFAOYSA-N | | SMILES | C1SC(Br)=CC=1C(OCC)=O |
| | Ethyl 5-bromothiophene-3-carboxylate Usage And Synthesis |
| Synthesis | 20 g (147 mmol) of aluminum chloride are added portion-wise to a solution of 10 g (67 mmol) of ethyl thiophene-3-carboxylate in 160 ml of dichloro-methane, cooled to 0oC. The reaction medium is warmed to room temperature, and a solution of 4 ml (73 mmol) of bromine in 10 ml of dichloromethane is added. After reaction for 50 minutes at room temperature, the reaction medium is poured into a water + ice mixture and extracted with dichloromethane. The organic phase is dried over magnesium sulfate, filtered, and evaporated under vacuum. The residue obtained is purified by chromatography on a column of silica eluted with a 9/1 HEPTANE/ETHYL acetate mixture. 9 g (57percent) of ethyl 5-bromothiophene-3-carboxylate are obtained.
| | Uses | Ethyl 5-bromothiophene-3-carboxylate is an important organic reagent that can be used as a building block for the synthesis of many organic compounds. After hydrolysis, it can synthesize 5-Bromothiophene-3-carboxylic acid. | | References | [1] Patent: WO2004/113331, 2004, A1. Location in patent: Page 39
[2] Patent: WO2007/145921, 2007, A1. Location in patent: Page/Page column 83-84 |
| | Ethyl 5-bromothiophene-3-carboxylate Preparation Products And Raw materials |
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