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| | 2'-deoxy-2'-fluoro-2'-C-methyluridine Basic information |
| Product Name: | 2'-deoxy-2'-fluoro-2'-C-methyluridine | | Synonyms: | 2'-deoxy-2'-fluoro-2'-C-methyluridine;2'-Deoxy-2-floro-2'Methyl-uridine;1-((2S,3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxyMethyl)-3-Methyltetrahydrofuran-2-yl)pyriMidine-2,4(1H,3H)-dione;1-((2R,3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxyMethyl)-3-Methyltetrahydrofuran-2-yl)pyriMidine-2,4(1H,3H)-dione;PSI-6206;RO 2433;Uridine, 2'-deoxy-2'-fluoro-2'-Methyl-, (2'R)-;Uridine, 2'-deoxy-2'-fluoro-2'-Methyl-, (2'R)- PSI6206 | | CAS: | 863329-66-2 | | MF: | C10H13FN2O5 | | MW: | 260.22 | | EINECS: | 810-481-6 | | Product Categories: | Sofosbuvir intermediate;Inhibitor;apis;Inhibitors | | Mol File: | 863329-66-2.mol |  |
| | 2'-deoxy-2'-fluoro-2'-C-methyluridine Chemical Properties |
| Melting point | 237-238℃ | | density | 1.55 | | storage temp. | Sealed in dry,Store in freezer, under -20°C | | solubility | DMSO (Slightly), Methanol (Slightly, Heated) | | pka | 9.39±0.10(Predicted) | | form | Solid | | color | White to Light Beige | | InChI | InChI=1S/C10H13FN2O5/c1-10(11)7(16)5(4-14)18-8(10)13-3-2-6(15)12-9(13)17/h2-3,5,7-8,14,16H,4H2,1H3,(H,12,15,17)/t5-,7-,8-,10-/m1/s1 | | InChIKey | ARKKGZQTGXJVKW-VPCXQMTMSA-N | | SMILES | OC[C@H]1O[C@@H](N2C=CC(=O)NC2=O)[C@@](F)(C)[C@@H]1O |
| | 2'-deoxy-2'-fluoro-2'-C-methyluridine Usage And Synthesis |
| Description | (2'R)-2'-Deoxy-2'-fluoro-2'-methyluridine / PSI-6206 is the deaminated metabolite of β-D-2'-Deoxy-2'-fluoro-2'-C-methylcytidine, an effective inhibitor of hepatitis C virus (HCV) RNA polymerase. | | Uses | RO 2433 is the deaminated metabolite of β-D-2''-Deoxy-2''-fluoro-2''-C-methylcytidine, an effective inhibitor of hepatitis C virus (HCV) replication in vitro. | | Biological Activity | psi-6206 (as known as ro-2433 or gs-331007), β-d-2’-deoxy-2’-fluoro-2’-c-methyluridine, is the deaminated derivative of psi-6130, β-d-2’-deoxy-2’-fluoro-2’-c-methylcytidine, which is a potent inhibitor of hepatitis c virus (hcv) replication in the subgenomic hcv reolicon system. psi-6206, itself, does not shown any inhibitory activity towards hcv replication in the hcv subgenomic replicon system. however, the its triphosphate form, ro2433-tp, is a potent inhibitor of rna synthesis by hcv polymerase, which inhibits both the rna sysnthesis activity of hcv replicase (ic50 = 1.19 um) and the rna synthesis activity of the recombinant hcv con1 ns58 on a heteropolymeric rna template derived from the 3’-end of the negative strand of the hcv genome (ic50 = 0.52 um and ki = 0.141 um).han ma, wen-rong jiang, nicole robledo, vincent leveque, samir ali, teresa lara-jamie, mohammad masjedizadeh, david b. smith, nick cammack, klaus klumpp, and julian symons. characterization of the metabolic ctivation of hepatitis c virus nucleoside inhibitor β-d-2’-deoxy-2’-fluoro-2’-c-methylcytidine (psi-6130) and identification of a novel active 5’-triphosphate species. the journal of biological chemistry 2007; 282(41): 29812-29820 | | target | HCV |
| | 2'-deoxy-2'-fluoro-2'-C-methyluridine Preparation Products And Raw materials |
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