TAI-1
| 中文名称 | TAI-1 |
|---|---|
| 中文同义词 | 化合物TAI1;N-(4-(4-(4-甲氧基苯氧基)-2,6-二甲基苯基)噻唑-2-基)异烟酰胺;化合物TAI1,10 MM DMSO 溶液 |
| 英文名称 | TAI-1 |
| 英文同义词 | N-(4-(4-(4-methoxyphenoxy)-2,6-dimethylphenyl)thiazol-2-yl)isonicotinamide;TAI 1;TAI1;4-Pyridinecarboxamide, N-[4-[4-(4-methoxyphenoxy)-2,6-dimethylphenyl]-2-thiazolyl]-;TAI-1 USP/EP/BP;TAI 1,TAI1,inhibit,Inhibitor,Apoptosis,TAI-1;TAI-1, 10 mM in DMSO |
| CAS号 | 1334921-03-7 |
| 分子式 | C24H21N3O3S |
| 分子量 | 431.51 |
| EINECS号 | |
| 相关类别 | 小分子抑制剂，天然产物;Inhibitors |
| Mol文件 | 1334921-03-7.mol |
| 结构式 |  |
TAI-1 性质
| 密度 | 1.281±0.06 g/cm3(Predicted) |
|---|---|
| 储存条件 | Store at -20°C |
| 溶解度 | DMSO 中≥43.2 mg/mL；不溶于水；乙醇中≥3.17 mg/mL |
| 形态 | 固体 |
| 酸度系数(pKa) | 5.38±0.70(Predicted) |
| 颜色 | 白色至米白色 |
TAI-1是一个有效的特异Hec1抑制剂，会打乱Hec1-Nek2蛋白质相互作用。TAI-1 disrupts the binding of Nek2 to Hec1, which leads to degradation of Nek2 and chromosomal misalignment. TAI-1 shows strong growth inhibitory potency at nM levels across a broad spectrum of tumor cells, and produces synergistic activity with doxorubicin, topotecan and paclitaxel in leukemia, breast and liver cancer cells.TAI-1 (20 mg/kg i.v. or 150 mg/kg p.o.) causes significant tumor growth delay in Huh-7 model and modest tumor inhibition in Colo205 and MDA-MB-231 models.