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| | 2'-Bromo-4-chlorophenylacetic acid methyl ester Basic information |
| Product Name: | 2'-Bromo-4-chlorophenylacetic acid methyl ester | | Synonyms: | 2-BROMO-4-CHLOROPHENYLACETIC ACID METHYL ESTER;Methyl-2-bromo-4-chlorophenylacetate;2-(2-broMo-4-chlorophenyl)propanoate;Methyl 2-broMo-2-(4-chlorophenyl)acetate;Methyl a-broMo-4-chlorophenylacetate;Benzeneacetic acid, .alpha.-bromo-4-chloro-, methyl ester;Benzeneacetic acid, α-bromo-4-chloro-, methyl ester;Methyl alpha-bromo-4-chlorophenylacetate | | CAS: | 24091-92-7 | | MF: | C9H8BrClO2 | | MW: | 263.52 | | EINECS: | 200-258-5 | | Product Categories: | Aromatic Esters | | Mol File: | 24091-92-7.mol |  |
| | 2'-Bromo-4-chlorophenylacetic acid methyl ester Chemical Properties |
| Boiling point | 149-152 °C(Press: 16 Torr) | | density | 1.567±0.06 g/cm3(Predicted) | | storage temp. | under inert gas (nitrogen or Argon) at 2-8°C | | Appearance | Colorless to light yellow Liquid | | CAS DataBase Reference | 24091-92-7(CAS DataBase Reference) |
| RIDADR | 1760 | | HazardClass | 8 | | PackingGroup | Ⅲ |
| | 2'-Bromo-4-chlorophenylacetic acid methyl ester Usage And Synthesis |
| Synthesis | General procedure for the synthesis of methyl 2'-bromo-4-chlorophenylacetate from methyl 4-chlorophenylacetate: Methyl 4-chlorophenylacetate (14.6 g, 79.1 mmol), N-bromosuccinimide (14.4 g, 80.7 mmol), and benzoyl peroxide (1.91 g, 7.89 mmol) were dissolved in carbon tetrachloride (100 mL) and heated to reflux for 3 hours. After completion of the reaction, the mixture was cooled to room temperature and diluted by adding hexane (500 mL). The reaction mixture was filtered and the solvent was subsequently evaporated under vacuum. The crude product was purified by silica column chromatography (eluent: ethyl acetate/hexane, 15:85) to afford methyl 2'-bromo-4-chlorophenylacetate as a colorless oil (16.9 g, 63% yield).1H NMR (400 MHz, CDCl3) δ 3.81 (s, 3H, CH3), 5.34 (s, 1H, CH), 7.44 (dd) ), J = 60.4 Hz, J = 8.4 Hz, 4H, ArH). | | References | [1] Tetrahedron, 2002, vol. 58, # 51, p. 10113 - 10126
[2] Patent: EP1712235, 2006, A2. Location in patent: Page/Page column 53
[3] Patent: US2004/220179, 2004, A1. Location in patent: Page 34
[4] Journal of Medicinal Chemistry, 1993, vol. 36, # 23, p. 3738 - 3742
[5] Patent: US2003/191190, 2003, A1 |
| | 2'-Bromo-4-chlorophenylacetic acid methyl ester Preparation Products And Raw materials |
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