| Company Name: |
Musechem |
| Tel: |
+1-800-259-7612 |
| Email: |
info@musechem.com |
MMAF-OMe manufacturers
- MMAF-OMe
-
- $52.00
-
2026-07-15
- CAS:863971-12-4
- Purity: 99.34%
- Supply Ability: 10g
- MMAF-OMe
-
- $52.00
-
2026-07-15
- CAS:863971-12-4
- Purity: 99.34%
- Supply Ability: 10g
|
| | MMAF-OMe Basic information |
| Product Name: | MMAF-OMe | | Synonyms: | MMAF-OMe;MONOMETHYL AURISTATIN F METHYL ESTER;L-Phenylalanine, N-methyl-L-valyl-L-valyl-(3R,4S,5S)-3-methoxy-5-methyl-4-(methylamino)heptanoyl-(αR,βR,2S)-β-methoxy-α-methyl-2-pyrrolidinepropanoyl-, methyl ester;ADC Payload,Inhibitor,MMAF-OMe,inhibit,MMAFOMe,MMAF OMe,ADC Cytotoxin;Methyl ((2R,3R)-3-((S)-1-((3R,4S,5S)-4-((S)-N,3-dimethyl-2-((S)-3-methyl-2-(methylamino)butanamido)butanamido)-3-methoxy-5-methylheptanoyl)pyrrolidin-2-yl)-3-methoxy-2-methylpropanoyl)-L-phenylalaninate;MMAF-OMe, 10 mM in DMSO;L-Phenylalanine,N-methyl-L-valyl-L-valyl-(3R,4S,5S)-3-methoxy-5-methyl-4-(methylamino)heptanoyl-(aR,bR,2S)-b-methoxy-a-methyl-2-pyrrolidinepropanoyl-,methyl ester | | CAS: | 863971-12-4 | | MF: | C40H67N5O8 | | MW: | 745.99 | | EINECS: | | | Product Categories: | | | Mol File: | 863971-12-4.mol |  |
| | MMAF-OMe Chemical Properties |
| Boiling point | 871.8±65.0 °C(Predicted) | | density | 1.095±0.06 g/cm3(Predicted) | | pka | 13.89±0.46(Predicted) | | form | Solid | | color | Off-white to light yellow |
| | MMAF-OMe Usage And Synthesis |
| Uses | MMAF-Ome, an antitubulin agent, is also an ADC cytotoxin. MMAF-Ome inhibits several tumor cell lines with IC50s of 0.056 nM, 0.166 nM, 0.183 nM, and 0.449 nM for MDAMB435/5T4, MDAMB361DYT2, MDAMB468, and Raji (5T4-) cell lines, respectively. | | IC 50 | Auristatin | | References | [1] Currier NV, et al. Targeted Drug Delivery with an Integrin-Binding Knottin-Fc-MMAF Conjugate Produced by Cell-Free Protein Synthesis. Mol Cancer Ther. 2016 Jun;15(6):1291-300 DOI:10.1158/1535-7163.MCT-15-0881 |
| | MMAF-OMe Preparation Products And Raw materials |
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