1H-Indazol-7-amine

1H-Indazol-7-amine Suppliers list

Company Name:	Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel:	4006356688 18621169109
Email:	market03@meryer.com

Company Name:	Wuhan Chemwish Technology Co., Ltd
Tel:	86-027-67849912
Email:	sales@chemwish.com

1H-Indazol-7-amine manufacturers

1H-Indazol-7-amine Basic information

Product Name:	1H-Indazol-7-amine
Synonyms:	1H-Indazol-7-amine ,97%;7-Amino-1H-indazole ,97%;1H-indazol-7-amine(SALTDATA: FREE);7-AMINO (1H)INDAZOLE;1H-Indazol-5-ylamine;1H-Indazol-7-ylaMine;7-AMinoindazole;7-Amino-1H-indazole 97%
CAS:	21443-96-9
MF:	C7H7N3
MW:	133.15
EINECS:	244-391-8
Product Categories:	Indazoles;pharmacetical;Amines;Fused Ring Systems;Indazole;Building Blocks
Mol File:	21443-96-9.mol

1H-Indazol-7-amine Chemical Properties

Melting point	157-163 °C
Boiling point	376.6±15.0 °C(Predicted)
density	1.367±0.06 g/cm3(Predicted)
RTECS	NK7713000
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
form	Crystalline Solid
pka	14.89±0.40(Predicted)
color	Tan
InChI	1S/C7H7N3/c8-6-3-1-2-5-4-9-10-7(5)6/h1-4H,8H2,(H,9,10)
InChIKey	OTFFCAGPSWJBDK-UHFFFAOYSA-N
SMILES	Nc1cccc2cn[nH]c12

Safety Information

Hazard Codes	Xi,Xn
Risk Statements	34-36/37/38-22
Safety Statements	26-36/37/39
RIDADR	3259
WGK Germany	3
HazardClass	IRRITANT
HS Code	29339900
Storage Class	11 - Combustible Solids
Hazard Classifications	Acute Tox. 4 Oral Eye Irrit. 2 Skin Irrit. 2 STOT SE 3

MSDS Information

1H-Indazol-7-amine Usage And Synthesis

Chemical Properties	Light yellow solid
Uses	1H-Indazol-7-amine is a substituted-indazole, an inhibitor of nitric oxide synthases.
Synthesis	2942-42-9 21443-96-9 General procedure for the synthesis of 7-aminoindazole from 7-nitroindazole: 7-nitroindazole (100 mg, 0.67 mmol) was dissolved in methanol (6 mL) and Pd/C (10 wt%) was added to the reaction vessel. The reaction mixture was stirred in H2 atmosphere for 12 h at room temperature. After completion of the reaction, the mixture was filtered through a diatomaceous earth pad, the filtrates were combined and concentrated, and finally the product was purified by column chromatography. The yield was 95% (85 mg); 1H-NMR (DMSO-d6, 300 MHz) δ 12.58 (1H, br, NH), 7.91 (1H, s, Ar-H), 6.93 (1H, d, J = 9.0 Hz, Ar-H), 6.83 (1H, t, J = 9.0 Hz, Ar-H), 6.46 (1H, d, J = 6.0 Hz, Ar-H), 5.30 (2H, br, NH2).
References	[1] Journal of Medicinal Chemistry, 2002, vol. 45, # 3, p. 740 - 743 [2] Archives of Pharmacal Research, 2018, vol. 41, # 1, p. 46 - 56 [3] Patent: US2006/270686, 2006, A1. Location in patent: Page/Page column 25 [4] Patent: US2008/280891, 2008, A1. Location in patent: Page/Page column 26 [5] Patent: WO2008/8059, 2008, A1. Location in patent: Page/Page column 65

1H-Indazol-7-amine Preparation Products And Raw materials

Raw materials	Acetic acid-->Sodium nitrite-->Palladium-->2-Methyl-6-nitroaniline-->7-Nitroindazole-->Activated carbon-->Methanol-->Hydrogen
Preparation Products	4,5,6,7-Tetrahydro-1H-indazol-7-amine

Tag:1H-Indazol-7-amine(21443-96-9) Related Product Information

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