- 1H-Indazol-7-amine
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- $0.00 / 1KG
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2025-04-04
- CAS:21443-96-9
- Min. Order: 1KG
- Purity: 98%
- Supply Ability: 1Ton
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| | 1H-INDAZOL-7-AMINE Basic information |
| | 1H-INDAZOL-7-AMINE Chemical Properties |
| Melting point | 157-163 °C | | Boiling point | 376.6±15.0 °C(Predicted) | | density | 1.367±0.06 g/cm3(Predicted) | | RTECS | NK7713000 | | storage temp. | Keep in dark place,Sealed in dry,Room Temperature | | form | Crystalline Solid | | pka | 14.89±0.40(Predicted) | | color | Tan | | InChI | 1S/C7H7N3/c8-6-3-1-2-5-4-9-10-7(5)6/h1-4H,8H2,(H,9,10) | | InChIKey | OTFFCAGPSWJBDK-UHFFFAOYSA-N | | SMILES | Nc1cccc2cn[nH]c12 |
| Hazard Codes | Xi,Xn | | Risk Statements | 34-36/37/38-22 | | Safety Statements | 26-36/37/39 | | RIDADR | 3259 | | WGK Germany | 3 | | HazardClass | IRRITANT | | HS Code | 29339900 | | Storage Class | 11 - Combustible Solids | | Hazard Classifications | Acute Tox. 4 Oral
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
| | 1H-INDAZOL-7-AMINE Usage And Synthesis |
| Chemical Properties | Light yellow solid | | Uses | 1H-Indazol-7-amine is a substituted-indazole, an inhibitor of nitric oxide synthases. | | Synthesis | General procedure for the synthesis of 7-aminoindazole from 7-nitroindazole: 7-nitroindazole (100 mg, 0.67 mmol) was dissolved in methanol (6 mL) and Pd/C (10 wt%) was added to the reaction vessel. The reaction mixture was stirred in H2 atmosphere for 12 h at room temperature. After completion of the reaction, the mixture was filtered through a diatomaceous earth pad, the filtrates were combined and concentrated, and finally the product was purified by column chromatography. The yield was 95% (85 mg); 1H-NMR (DMSO-d6, 300 MHz) δ 12.58 (1H, br, NH), 7.91 (1H, s, Ar-H), 6.93 (1H, d, J = 9.0 Hz, Ar-H), 6.83 (1H, t, J = 9.0 Hz, Ar-H), 6.46 (1H, d, J = 6.0 Hz, Ar-H), 5.30 (2H, br, NH2). | | References | [1] Journal of Medicinal Chemistry, 2002, vol. 45, # 3, p. 740 - 743
[2] Archives of Pharmacal Research, 2018, vol. 41, # 1, p. 46 - 56
[3] Patent: US2006/270686, 2006, A1. Location in patent: Page/Page column 25
[4] Patent: US2008/280891, 2008, A1. Location in patent: Page/Page column 26
[5] Patent: WO2008/8059, 2008, A1. Location in patent: Page/Page column 65 |
| | 1H-INDAZOL-7-AMINE Preparation Products And Raw materials |
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