5,6-Dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a]thieno[2,3-f][1,4]diazepine-3-carboxylic acid 1,1-dimethylethyl ester

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5,6-Dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a]thieno[2,3-f][1,4]diazepine-3-carboxylic acid 1,1-dimethylethyl ester manufacturers

  • Ro 19-4603
  • Ro 19-4603 pictures
  • $2500.00
  • 2026-05-11
  • CAS:99632-94-7
  • Purity:
  • Supply Ability: 10g
5,6-Dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a]thieno[2,3-f][1,4]diazepine-3-carboxylic acid 1,1-dimethylethyl ester Basic information
Product Name:5,6-Dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a]thieno[2,3-f][1,4]diazepine-3-carboxylic acid 1,1-dimethylethyl ester
Synonyms:RO 19-4603;5,6-Dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a]thieno[2,3-f][1,4]diazepine-3-carboxylicacid1,1-dimethylethylester;4H-Imidazo[1,5-a]thieno[2,3-f][1,4]diazepine-3-carboxylic acid, 5,6-dihydro-5-methyl-6-oxo-, 1,1-dimethylethyl ester;Ro 194603,Ro 19 4603;5,6-Dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a]thieno[2,3-f][1,4]diazepine-3-carboxylic acid 1,1-dimethylethyl ester
CAS:99632-94-7
MF:C15H17N3O3S
MW:319.38
EINECS:
Product Categories:
Mol File:99632-94-7.mol
5,6-Dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a]thieno[2,3-f][1,4]diazepine-3-carboxylic acid 1,1-dimethylethyl ester Structure
5,6-Dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a]thieno[2,3-f][1,4]diazepine-3-carboxylic acid 1,1-dimethylethyl ester Chemical Properties
storage temp. Store at RT
solubility <31.94mg/ml in ethanol; <31.94mg/ml in DMSO
Safety Information
MSDS Information
5,6-Dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a]thieno[2,3-f][1,4]diazepine-3-carboxylic acid 1,1-dimethylethyl ester Usage And Synthesis
UsesRo 19-4603 is a novel benzodiazepine inverse agonist.
DefinitionChEBI: Ro 19-4603 is an organonitrogen heterocyclic compound, an organosulfur heterocyclic compound and a tert-butyl ester.
Biological ActivityBenzodiazepine inverse agonist. Binds with high affinity to both diazepam-sensitive (DS) and diazepam-insensitive (DI) GABA A receptors (K i values are ~ 0.2 and ~ 2.6 nM for DS and DI receptors respectively). Antagonizes effects of ethanol on locomotor behavior and suppresses ethanol intake in alcohol-preferring rats.
in vivo

Ro19-4603 (0-0.3 mg/kg, i.p.) markedly reduces EtOH intake at the 8-h interval in alcohol-preferring rats[1].

Animal Model:Alcohol-Preferring rats[1]
Dosage:0.075, 0.150, and 0.30 mg/kg.
Administration:i.p.
Result:Reduced EtOH intake at the 8-h interval, but no apparent effect at the 24-h interval.
5,6-Dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a]thieno[2,3-f][1,4]diazepine-3-carboxylic acid 1,1-dimethylethyl ester Preparation Products And Raw materials
Tag:5,6-Dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a]thieno[2,3-f][1,4]diazepine-3-carboxylic acid 1,1-dimethylethyl ester(99632-94-7) Related Product Information
1-Methyl-1H-imidazole-4-carboxylic acid 1-METHYL-1H-IMIDAZOLE-4-CARBOXYLIC ACID METHYL ESTER 5,6-Dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a]thieno[2,3-f][1,4]diazepine-3-carboxylic acid 1,1-dimethylethyl ester 1,5-Dimethyl-1H-imidazole-4-carbaldehyde (1-Methyl-1H-imidazol-4-yl)methanol DHEA-S