PF-06372865 manufacturers
- Darigabat
-
- $49.00
-
2026-07-15
- CAS:1614245-70-3
- Purity: 99.29%
- Supply Ability: 10g
|
| | PF-06372865 Basic information |
| Product Name: | PF-06372865 | | Synonyms: | PF-06372865;7H-Imidazo[4,5-c]pyridazine, 7-ethyl-4-[4'-(ethylsulfonyl)-6-fluoro-2'-methoxy[1,1'-biphenyl]-3-yl]-;PF06372865,PF 06372865;7-Ethyl-4-(4'-(ethylsulfonyl)-6-fluoro-2'-methoxy-[1,1'-biphenyl]-3-yl)-7H-imidazo[4,5-c]pyridazine;CVL-865|||PF-6372865|||PF-06372865;Darigabat, 10 mM in DMSO;CVL-865;Darigabat | | CAS: | 1614245-70-3 | | MF: | C22H21FN4O3S | | MW: | 440.49 | | EINECS: | | | Product Categories: | | | Mol File: | 1614245-70-3.mol |  |
| | PF-06372865 Chemical Properties |
| Melting point | 184 - 186°C | | Boiling point | 577.2±60.0 °C(Predicted) | | density | 1.35±0.1 g/cm3(Predicted) | | storage temp. | -20°C Freezer, Under inert atmosphere | | solubility | Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly, Heated) | | form | Solid | | pka | -0.55±0.30(Predicted) | | color | White to Light Beige |
| | PF-06372865 Usage And Synthesis |
| Uses | PF 06372865 are used as GABAA receptor modulators to treat pain. | | in vivo | PF-06372865 (compound 34; 3, 10 mg/kg; orally; single dose) significantly increases the paw withdrawal threshold (PWT) in chronic constriction injury (CCI) animals[1].
PF-06372865 (0.3, 3, 10 mg/kg for mouse and 1, 3, 10 mg/kg for rat; orally) exhibits efficacy in two models of epilepsy, PTZ induced seizures (mouse), and amygdala kindling (rat)[1].
PF-06372865 (0.1, 0.32, 1, 3.2 and 10 mg/kg; orally) has anxiolytic activity at 3.2 and 10 mg/kg in elevated plus maze (male C57Bl/6 mice)[1].
PF-06372865 has a T1/2 of 1.1 hours, a Clp of 22 mL/min/kg, and a Vss of 2.1 L/kg for rats[1].
PF-06372865 has a T1/2 of 0.9 hours, a Clp of 29 mL/min/kg, and a Vss of 3.4 L/kg for dogs[1].
| Animal Model: | Chronic constriction injury (CCI) model (male Wistar rats)[1] | | Dosage: | 3, 10 mg/kg | | Administration: | Orally | | Result: | Significantly increased paw withdrawal latency.
|
|
| | PF-06372865 Preparation Products And Raw materials |
|