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COX-2 (human) Inhibitor Screening Assay Kit

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COX-2 (human) Inhibitor Screening Assay Kit Basic information
Product Name:COX-2 (human) Inhibitor Screening Assay Kit
Synonyms:COX-2 (human) Inhibitor Screening Assay Kit
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COX-2 (human) Inhibitor Screening Assay Kit Structure
COX-2 (human) Inhibitor Screening Assay Kit Chemical Properties
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COX-2 (human) Inhibitor Screening Assay Kit Usage And Synthesis
DescriptionCOX-1 and COX-2 catalyze the production of the prostaglandin (PG) and thromboxane precursor PGH2. COX-2 is primarily responsible for the biosynthesis of PGs under acute inflammatory conditions. The COX-2 (human recombinant) Inhibitor Screening Assay measures PGF2α that is produced by SnCl2 reduction of COX-2-derived PGH2. PGF2α is quantified via enzyme immunoassay (EIA) using a broadly specific antiserum that binds to all the major PG compounds. This assay includes human recombinant COX-2 and is an excellent tool which can be used for general inhibitor screening, or to eliminate false positive leads generated by less specific methods.
References[1] LINLIN XIE . Characterization of spirostanol glycosides and furostanol glycosides from anemarrhenae rhizoma as dual targeted inhibitors of 5-lipoxygenase and Cyclooxygenase-2 by employing a combination of affinity ultrafiltration and HPLC/MS[J]. Phytomedicine, 2020, 77: Article 153284. DOI: 10.1016/j.phymed.2020.153284
[2] MOSAAD S MOHAMED. Molecular modelling insights into a physiologically favourable approach to eicosanoid biosynthesis inhibition through novel thieno[2,3-b]pyridine derivatives.[J]. Journal of Enzyme Inhibition and Medicinal Chemistry, 2018, 33 1: 755-767. DOI: 10.1080/14756366.2018.1457657
COX-2 (human) Inhibitor Screening Assay Kit Preparation Products And Raw materials
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