2,5-Dioxopyrrolidin-1-yl 4-((5-nitropyridin-2-yl)disulfanyl)pentanoate

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2,5-Dioxopyrrolidin-1-yl 4-((5-nitropyridin-2-yl)disulfanyl)pentanoate Basic information
Product Name:2,5-Dioxopyrrolidin-1-yl 4-((5-nitropyridin-2-yl)disulfanyl)pentanoate
Synonyms:2,5-Dioxopyrrolidin-1-yl 4-((5-nitropyridin-2-yl)disulfanyl)pentanoate;NO2-SPP;Pentanoic acid, 4-[(5-nitro-2-pyridinyl)dithio]-, 2,5-dioxo-1-pyrrolidinyl ester
CAS:663598-61-6
MF:C14H15N3O6S2
MW:385.42
EINECS:
Product Categories:
Mol File:663598-61-6.mol
2,5-Dioxopyrrolidin-1-yl 4-((5-nitropyridin-2-yl)disulfanyl)pentanoate Structure
2,5-Dioxopyrrolidin-1-yl 4-((5-nitropyridin-2-yl)disulfanyl)pentanoate Chemical Properties
Boiling point 548.7±60.0 °C(Predicted)
density 1.51±0.1 g/cm3(Predicted)
pka-2.22±0.29(Predicted)
Safety Information
MSDS Information
2,5-Dioxopyrrolidin-1-yl 4-((5-nitropyridin-2-yl)disulfanyl)pentanoate Usage And Synthesis
UsesNO2-SPP is a cleavable linker that is used for making antibody-drug conjugate (ADC).
IC 50Disulfide Cleavable Linker; Cleavable Linker
References[1] Qiming Chen, et al. Anti-integrin immunoconjugates, methods and uses. WO2006062779A2.
2,5-Dioxopyrrolidin-1-yl 4-((5-nitropyridin-2-yl)disulfanyl)pentanoate Preparation Products And Raw materials
Tag:2,5-Dioxopyrrolidin-1-yl 4-((5-nitropyridin-2-yl)disulfanyl)pentanoate(663598-61-6) Related Product Information
SNPB N-succiniMidyl 4-(2-pyridyldithio)pentanoate Py-ds-dMBut-OSu SPDB 2,5-Dioxopyrrolidin-1-yl 4-methyl-4-((5-nitropyridin-2-yl)disulfanyl)pentanoate 3-(Methylsulfonyl)-2,5-dioxopyrrolidin-1-yl 4-((5-nitropyridin-2-yl)disulfanyl)pentanoate