| Company Name: |
3B Pharmachem (Wuhan) International Co.,Ltd.
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| Tel: |
821-50328103-801 18930552037 |
| Email: |
3bsc@sina.com |
| Products Intro: |
Product Name:N-Acetyl-L-leucyl-L-leucyl-L-Methional
CAS:136632-32-1
Purity:99% HPLC Package:1Mg ; 5Mg;10Mg ;100Mg;250Mg ;500Mg ;1g;2.5g ;5g ;10g
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| | 25 MG CALPAIN INHIBITOR IIRESEARCH GRADE Basic information |
| | 25 MG CALPAIN INHIBITOR IIRESEARCH GRADE Chemical Properties |
| storage temp. | −20°C | | solubility | Soluble in ethanol at 20mg/ml | | form | powder | | color | white | | BRN | 7693643 | | Stability: | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month. |
| | 25 MG CALPAIN INHIBITOR IIRESEARCH GRADE Usage And Synthesis |
| Description | ALLM (136632-32-1) is a cell-permeable, peptide aldehyde inhibitor of calpain (calpain I, Ki= 120 nM, calpain II, Ki= 230 nM) and other neutral cysteine proteases. Potent inhibitor of cathepsin L (Ki=0.6 nM) and cathepsin B (Ki=100 nM).1Weak inhibitor of the chymotrypsin-like activity of the proteasome.2Cell permeable. | | Uses | ALLM (Calpain Inhibitor) is a cell-permeable, peptide aldehyde inhibitor of calpain I and calpain II. ALLM acts as a very potent inhibitor of cathepsin L and the strongest inhibitor of cathepsin B amongst the peptide aldehydes. This compound inhibits the processing of malaria aspartic hemoglobinases plasmepsins I and IIin vitro. ALLM also inhibits other neutral cysteine proteases, and activation-induced programmed cell death. It restores defective immune responses in HIV+ donors. ALLM blocks nitric oxide production by activated macrophages by interfering with transcription of the inducible nitric oxide synthase gene. ALLM also acts as a weak inhibitor of proteasome. | | Uses | Calpain inhibitor II is a cell-permeable peptide that restricts the activity of calpain, cathepsin L and cathepsin B. Calpain inhibitor II also prevents the methylmercury-induced cell death of cultured rat cerebellar neurons. | | Definition | ChEBI: (2S)-2-acetamido-4-methyl-N-[4-methyl-1-[[4-(methylthio)-1-oxobutan-2-yl]amino]-1-oxopentan-2-yl]pentanamide is a peptide. | | References | [1] T SASAKI. Inhibitory effect of di- and tripeptidyl aldehydes on calpains and cathepsins.[J]. Journal of enzyme inhibition, 1990, 3 3: 195-201. DOI:10.3109/14756369009035837
[2] ALEXANDER VINITSKY. Inhibition of the chymotrypsin-like activity of the pituitary multicatalytic proteinase complex[J]. Biochemistry Biochemistry, 1992, 31 39: 9421-9428. DOI:10.1021/bi00154a014 |
| | 25 MG CALPAIN INHIBITOR IIRESEARCH GRADE Preparation Products And Raw materials |
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