|
|
| | DL-TYROSINE METHYL ESTER HCL Basic information |
| Product Name: | DL-TYROSINE METHYL ESTER HCL | | Synonyms: | methyl DL-tyrosinate hydrochloride;(±)-Tyrosine methyl ester hydrochloride;2-Amino-3-(4-hydroxyphenyl)propionic acid methyl ester hydrochloride;Methyl 2-amino-3-(4-hydroxyphenyl);DL-TYROSINE METHYL ESTER HCL;H-DL-Tyr-OMe;DL-Tyr-Ome.HCl;DL-TYROSINE METHYL ESTER HCL USP/EP/BP | | CAS: | 68697-61-0 | | MF: | C10H14ClNO3 | | MW: | 231.67606 | | EINECS: | 272-084-9 | | Product Categories: | | | Mol File: | 68697-61-0.mol |  |
| | DL-TYROSINE METHYL ESTER HCL Chemical Properties |
| Melting point | 192-193° | | storage temp. | Inert atmosphere,2-8°C | | Appearance | White to off-white Solid |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26-36 | | WGK Germany | 3 |
| | DL-TYROSINE METHYL ESTER HCL Usage And Synthesis |
| Synthesis | Under argon protection, D,L-tyrosine (10.0 g, 55.1 mmol) was dissolved in methanol (88 mL) and the reaction system was cooled to 0°C. Subsequently, thionyl chloride (3.97 mL, 60.6 mmol) was added slowly and dropwise. Upon completion of the reaction, the reaction solution was concentrated under reduced pressure. The resulting crude product was purified by recrystallization from a solvent mixture of methanol (5 mL) and diethyl ether (80 mL) to afford the target product L-tyrosine methyl ester hydrochloride (10.8 g). | | References | [1] Acta Chimica Academiae Scientiarum Hungaricae, 1981, vol. 107, # 1, p. 7 - 9
[2] European Journal of Medicinal Chemistry, 1986, vol. 21, # 4, p. 333 - 338
[3] Chemical Communications, 2008, # 30, p. 3528 - 3530
[4] Advanced Synthesis and Catalysis, 2012, vol. 354, # 17, p. 3327 - 3332
[5] Angewandte Chemie - International Edition, 2013, vol. 52, # 49, p. 12942 - 12945 |
| | DL-TYROSINE METHYL ESTER HCL Preparation Products And Raw materials |
|