Homo-PROTAC cereblon degrader 1 manufacturers
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| | Homo-PROTAC cereblon degrader 1 Basic information |
| Product Name: | Homo-PROTAC cereblon degrader 1 | | Synonyms: | Homo-PROTAC cereblon degrader 1;4,4'-(((Ethane-1,2-diylbis(oxy))bis(ethane-2,1-diyl))bis(azanediyl))bis(2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione);Homo-PROTAC cereblon degrader 1,PROTACs,Inhibitor,inhibit,HomoPROTAC cereblon degrader 1,Homo PROTAC cereblon degrader 1;2-(2,6-dioxopiperidin-3-yl)-4-({2-[2-(2-{[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl]amino}ethoxy)ethoxy]ethyl}amino)-2,3-dihydro-1H-isoindole-1,3-dione;Homo-PROTAC cereblon degrader 1 ，S2881;1H-Isoindole-1,3(2H)-dione, 4,4′-[1,2-ethanediylbis(oxy-2,1-ethanediylimino)]bis[2-(2,6-dioxo-3-piperidinyl)-;CRBN PROTAC compound I | | CAS: | 2244520-98-5 | | MF: | C32H32N6O10 | | MW: | 660.64 | | EINECS: | | | Product Categories: | | | Mol File: | 2244520-98-5.mol |  |
| | Homo-PROTAC cereblon degrader 1 Chemical Properties |
| Boiling point | 978.5±65.0 °C(Predicted) | | density | 1.527±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMSO: 200 mg/mL (302.74 mM) | | pka | 10.44±0.40(Predicted) | | form | Solid | | color | Light yellow to yellow |
| | Homo-PROTAC cereblon degrader 1 Usage And Synthesis |
| Description | Homo-PROTAC Cereblon Degrader 1 is a highly potent and efficient Cereblon (CRBN) degrader with minimal effects on IKZF1 and IKZF3. | | Uses | Homo-PROTAC cereblon degrader 1 (compound 15a) is a highly potent and efficient Cereblon (CRBN) degrader with only minimal effects on IKZF1 and IKZF3[1]. | | IC 50 | Cereblon | | References | [1] Steinebach C, et al. Homo-PROTACs for the Chemical Knockdown of Cereblon. ACS Chem Biol. 2018 Sep 21;13(9):2771-2782. DOI:10.1021/acschembio.8b00693 |
| | Homo-PROTAC cereblon degrader 1 Preparation Products And Raw materials |
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