Homo-PROTAC cereblon degrader 1 NEW
| Price | $71 | $172 | $297 |
| Package | 1mg | 5mg | 10mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-12-05 |
Product Details
| Product Name: Homo-PROTAC cereblon degrader 1 | CAS No.: 2244520-98-5 |
| Purity: 98.30% | Supply Ability: 10g |
| Release date: 2025/12/05 |
Product Introduction
Bioactivity
| Name | Homo-PROTAC cereblon degrader 1 |
| Description | Homo-PROTAC cereblon degrader 1 is a highly potent and efficient cereblon (CRBN) degrader with only minimal effects on IKZF1 and IKZF3. |
| In vitro | Homo-PROTAC cereblon degrader 1 (0-1 μM, 16 hours) effectively reduces Cereblon protein levels in the multiple myeloma cell line NCI-H929. Experimental results indicate that the effect is observed at a concentration of 10 nM after 16-hour incubation. The degradation efficiency reaches its peak at concentrations between 100 nM and 1 μM. However, when the concentration is further increased to 100 μM, the degradation of Cereblon is completely inhibited [1]. When MM1S cells were treated with Homo-PROTAC cereblon degrader 1 (100 nM, 0-24 hours), cereblon protein levels decreased within 15 minutes and peaked at 6 hours [1]. The effects of homo-PROTAC cerebrone degrader 1 (0-10 μM, 4 days) on the proliferation of palomidomide-sensitive multiple myeloma cell lines MM1S, NCI-H929, LP-1, KMS27, and RPMI 8226 were investigated. The results showed that Homo-PROTAC cereblon degrader 1 had little effect on the proliferation of the cells at concentrations of ≤1 μM [1]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 200 mg/mL (302.74 mM), Sonication is recommended. 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 5 mg/mL (7.57 mM), Sonication is recommended. |
| Keywords | PROTACs | Inhibitor | inhibit | Homo-PROTAC cereblon degrader 1 | HomoPROTAC cereblon degrader 1 | Homo PROTAC cereblon degrader 1 | Cereblon |
| Inhibitors Related | ARV-393 HCl | ACBI1 | ARV-471 | CCT367766 | dBET6 | Dbet57 | dBET1 | ARV-825 | Lenalidomide | AU-15330 | β-NF-JQ1 | C004019 |
| Related Compound Libraries | Bioactive Compound Library | Bioactive Compounds Library Max |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, USA
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