(R)-CPP

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Company Name: TargetMol Chemicals Inc.
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CAS:126453-07-4
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CAS:126453-07-4
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CAS:126453-07-4
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Company Name: Hangzhou MolCore BioPharmatech Co.,Ltd.
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CAS:126453-07-4
Purity:NLT 98% Remarks:MC515509
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  • (R)-CPP
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  • $133.00
  • 2026-05-11
  • CAS:126453-07-4
  • Purity:
  • Supply Ability: 10g
(R)-CPP Basic information
Product Name:(R)-CPP
Synonyms:(R)-CPP;(R)-CCP;R(-)-3-(2-CARBOXYPIPERAZIN-4-YL)-PROPYL-1-PHOSPHONIC ACID;D-CPP;3-((R)-2-CARBOXYLPIPERAZIN-4-YL)-PROPYL-1-PHOSPHONIC ACID;3-((R)-2-CARBOXYPIPERAZIN-4-YL)-PROPYL-1-PHOSPHONIC ACID;3-((R)-Carboxylpiperazin-4-yl)-propyl-1-phosphonic acid;rac-(2R*)-2-(2,4-Dichlorophenoxy)propanoic acid
CAS:126453-07-4
MF:C8H17N2O5P
MW:252.2
EINECS:
Product Categories:Glutamate;Glutamate receptor
Mol File:126453-07-4.mol
(R)-CPP Structure
(R)-CPP Chemical Properties
Boiling point 546.7±60.0 °C(Predicted)
density 1.408±0.06 g/cm3(Predicted)
storage temp. Desiccate at RT
solubility Water: 100mM
form White crystalline powder.
pka1.89±0.20(Predicted)
color White to off-white
Water Solubility Soluble to 100 mM in water
Safety Information
MSDS Information
(R)-CPP Usage And Synthesis
Description(R)-CPP is an NMDA receptor antagonist (Ki = 0.14 μM). It binds to NMDA receptors containing GluN2A, GluN2B, GluN2C, and GluN2D subunits with Ki values of 0.04, 0.3, 0.6, and 2 μM, respectively. It inhibits depolarization induced by NMDA in isolated hemisected frog spinal cord (pA2 = 6.56) and NMDA-induced sodium efflux from rat brain slices (pA2 = 6.2). (R)-CPP inhibits the clonic phase of sound-induced seizures in DBA/2 mice (ED50 = 65.8 μmol/kg) and the myoclonic phase of stroboscopic-induced seizures in P. papio photosensitive baboons (ED50 = 127 μmol/kg).
Uses(R)-CPP is a piperazine derivative demonstrating highly potent NMDA receptor antagonism.
Biological ActivityHighly potent NMDA antagonist; more active isomer. Shows some selectivity for NR2A-containing receptors (K i values are 0.041, 0.27, 0.63 and 1.99 μ M for inhibition of NR2A-, NR2B-, NR2C- and NR2D-containing recombinant NMDA receptors respectively).
IC 50NMDA Receptor
storageRoom temperature (desiccate)
References[1] B. AEBISCHER. ChemInform Abstract: Synthesis and NMDA Antagonistic Properties of the Enantiomers of 4-(3-Phosphonopropyl)piperazine-2-carboxylic Acid (CPP) and of the Unsaturated Analogue (E)-4-(3-Phosphonoprop-2-enyl)piperazine-2-carboxylic Acid (CPP-ene).[J]. ChemInform, 1989, 20 44. DOI: 10.1002/chin.198944252
[2] P. PAOLETTI  J. N. NMDA receptor subunits: Function and pharmacology[J]. Acute Pain, 2007, 9 2: Page 97. DOI: 10.1016/j.acpain.2007.04.009
[3] SMITA PATEL . Anticonvulsant activity of the NMDA antagonists, d()4-(3-phosphonopropyl)piperazine-2-carboxylic acid (D-CPP) and d()(E)-4-(3-phosphonoprop-2-enyl) piperazine-2-carboxylic acid (D-CPPene) in a rodent and a primate model of reflex epilepsy[J]. Epilepsy Research, 1990, 7 1: Pages 3-10. DOI: 10.1016/0920-1211(90)90049-2
(R)-CPP Preparation Products And Raw materials
Raw materials117414-78-5-->D-4-[(2E)-3-PHOSPHONO-2-PROPENYL]-2-PIPERAZINECARBOXYLIC ACID
Tag:(R)-CPP(126453-07-4) Related Product Information
2-Piperazinemethanol (R)-PIPERAZINE-2-CARBOXYLIC ACID PIPERAZINE-2-CARBOXYLIC ACID D-SS-(N-METHYLAMINO)ALANINE 3-(N,N-Dimethylamino)-D-alanine D-2,3-Diaminopropionic acid 3-Aminopropylphosphonic acid 3-(N,N-Diethylamino)-L-alanine (R)-CPP 4-CPP 4-METHYLPIPERAZINE-2-CARBOXYLIC ACID 2-Piperazinecarboxaldehyde Aminoacylproline Carboxypeptidase, CPP, Penicillocarboxypeptidase S-1, Proline Carboxypeptidase,CPP【NMDA receptor antagonist】 CHLORINATEDPOLYPROPYLENE(CPP) (R)-2-(2,4-Dichlorophenoxy)propanoic acid azaleucine [CPP1-7, NPY19-23, Ala31, Aib32, Gln34]-Pancreatic polypeptide (+/-)-3-(2-CARBOXYPIPERAZIN-4-YL)-PROPYL-1-PHOSPHONIC ACID