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| | 4,6-Dichloro-5-methylpyrimidine Basic information | | Application |
| Product Name: | 4,6-Dichloro-5-methylpyrimidine | | Synonyms: | 4,6-DICHLORO-5-METHYLPYRIMIDINE;4,6-DICHLORO-5-METHYLPYRIMIDIN;4-chloro-6-methoxy-5-methylpyrimidine;4,6-Dichloro-5-methyl-1,3-diazine;4,6-Dichloro-5-MethylpyriMidine, 97+%;Pyrimidine, 4,6-dichloro-5-methy;Pyrimidine, 4,6-dichloro-5-methyl-;4,6-Dichloro-5-methylpyrimidine> | | CAS: | 4316-97-6 | | MF: | C5H4Cl2N2 | | MW: | 163 | | EINECS: | | | Product Categories: | Heterocycle-Pyrimidine series;PyrimidinesHeterocyclic Building Blocks;Heterocyclic Compounds;Bases & Related Reagents;Heterocycles;Nucleotides;Building Blocks;Halogenated Heterocycles;Heterocyclic Building Blocks;Pyrimidines | | Mol File: | 4316-97-6.mol |  |
| | 4,6-Dichloro-5-methylpyrimidine Chemical Properties |
| Melting point | 56-60 °C (lit.) | | storage temp. | Inert atmosphere,2-8°C | | solubility | soluble in Methanol | | form | powder to crystal | | color | White to Light yellow to Light orange | | InChI | 1S/C5H4Cl2N2/c1-3-4(6)8-2-9-5(3)7/h2H,1H3 | | InChIKey | NUEYDUKUIXVKNB-UHFFFAOYSA-N | | SMILES | Cc1c(Cl)ncnc1Cl | | CAS DataBase Reference | 4316-97-6(CAS DataBase Reference) |
| Hazard Codes | C | | Risk Statements | 34 | | Safety Statements | 26-36/37/39-45 | | RIDADR | UN 3261 8/PG 2 | | WGK Germany | 3 | | HazardClass | 8 | | HazardClass | CORROSIVE | | HS Code | 29335990 | | Storage Class | 8A - Combustible corrosive hazardous materials | | Hazard Classifications | Eye Dam. 1
Skin Corr. 1B |
| | 4,6-Dichloro-5-methylpyrimidine Usage And Synthesis |
| Application | 4,6-Dichloro-5-methylpyrimidine is a heterocyclic organic compound that can be used as an intermediate in organic synthesis. | | Chemical Properties | White Solid | | Synthesis | General procedure for the synthesis of 4,6-dichloro-5-methylpyrimidine from 5-methylpyrimidine-4,6-diol: To a solution of POCl3 (1.9 mol, 174 mL) containing the pyrimidine derivative (0.38 mol, 1 eq.) was slowly added DMF (0.152 mol, 11.7 mL), noting that this process is exothermic. The reaction mixture was heated to reflux and maintained for 3 hours. Upon completion of the reaction, it was cooled to room temperature and the mixture was carefully poured into an ice/water mixture. The precipitated white solid product was collected by filtration, washed well with water and subsequently dried under vacuum to afford 4,6-dichloro-5-methylpyrimidine (1) in 90% yield. | | References | [1] Patent: US2006/155129, 2006, A1. Location in patent: Page/Page column 14
[2] Patent: EP1333029, 2003, A1 |
| | 4,6-Dichloro-5-methylpyrimidine Preparation Products And Raw materials |
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