|
|
| | THIAZOLE-2-CARBOXYLIC ACID Basic information |
| | THIAZOLE-2-CARBOXYLIC ACID Chemical Properties |
| Melting point | 91.6-93°C | | Boiling point | 310.6±25.0 °C(Predicted) | | density | 1.525±0.06 g/cm3(Predicted) | | storage temp. | -20°C | | form | Solid | | pka | 2.95±0.10(Predicted) | | Appearance | White to off-white Solid | | Water Solubility | Slightly soluble in water. | | InChI | 1S/C4H3NO2S/c6-4(7)3-5-1-2-8-3/h1-2H,(H,6,7) | | InChIKey | IJVLVRYLIMQVDD-UHFFFAOYSA-N | | SMILES | OC(=O)c1nccs1 | | CAS DataBase Reference | 14190-59-1(CAS DataBase Reference) |
| | THIAZOLE-2-CARBOXYLIC ACID Usage And Synthesis |
| Chemical Properties | Beige to light yellow powder | | Uses | Thiazole-2-carboxylic acid is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuff. | | Synthesis | General procedure for the synthesis of thiazole-2-carboxylic acid from ethyl 2-thiazolecarboxylate: 2N aqueous KOH solution (3.5 mL, 5 eq.) was added to a solution of ethyl 2-thiazolecarboxylate (213 mg, 1.355 mmol) in ethanol (3 mL) at 116 °C. The reaction mixture was stirred at room temperature for 2 hours and then acidified with 2N HCl (3.5 mL). The acidified mixture was allowed to stand overnight and needle-like crystals were precipitated and collected by filtration to give thiazole-2-carboxylic acid (43.3 mg, 25% yield). | | References | [1] Patent: US2007/185056, 2007, A1. Location in patent: Page/Page column 49
[2] Helvetica Chimica Acta, 1945, vol. 28, p. 924
[3] Patent: WO2008/76243, 2008, A2. Location in patent: Page/Page column 75
[4] Patent: WO2008/85316, 2008, A1. Location in patent: Page/Page column 73
[5] Patent: WO2006/138373, 2006, A2. Location in patent: Page/Page column 128-129 |
| | THIAZOLE-2-CARBOXYLIC ACID Preparation Products And Raw materials |
|