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| | 6-Chloro-2,3-diaminopyridine Basic information | | Application |
| Product Name: | 6-Chloro-2,3-diaminopyridine | | Synonyms: | 6-Chloro-2,3-diaminopyridine;2,3-Diamino-6-chloropyridine ,97%;6-chloro-2,3-PyridinediaMine;2,3-PyridinediaMine, 6-chloro-;6-chloro-pyridine-2,3-diyldiamine;2,3-Diamino-6-chloropyridine ;6-Chloro-2,3-diaminopyridine ISO 9001：2015 REACH;6-Chloropyridine-2,3-diamin | | CAS: | 40851-95-4 | | MF: | C5H6ClN3 | | MW: | 143.57 | | EINECS: | 214-589-6 | | Product Categories: | Heterocycle-Pyridine series | | Mol File: | 40851-95-4.mol |  |
| | 6-Chloro-2,3-diaminopyridine Chemical Properties |
| Melting point | 132.0 to 136.0 °C | | Boiling point | 360.2±37.0 °C(Predicted) | | density | 1.447±0.06 g/cm3(Predicted) | | storage temp. | 2-8°C | | pka | 2.69±0.50(Predicted) | | form | powder to crystal | | color | White to Brown to Dark purple | | InChI | 1S/C5H6ClN3/c6-4-2-1-3(7)5(8)9-4/h1-2H,7H2,(H2,8,9) | | InChIKey | QEIRYIILFUVXAM-UHFFFAOYSA-N | | SMILES | ClC1=NC(N)=C(N)C=C1 |
| Hazard Codes | Xn | | Risk Statements | 22-36/37/38-42/43-33-23/24/25 | | Safety Statements | 22-36/37-45-37-28 | | RIDADR | 2811 | | WGK Germany | 3 | | HazardClass | 6.1 | | HS Code | 29333990 | | Storage Class | 11 - Combustible Solids | | Hazard Classifications | Acute Tox. 4 Oral
Eye Irrit. 2
Resp. Sens. 1
Skin Irrit. 2
Skin Sens. 1
STOT SE 3 |
| | 6-Chloro-2,3-diaminopyridine Usage And Synthesis |
| Application | 6-Chloro-2,3-diaminopyridine is an organic synthesis intermediate and a pharmaceutical intermediate that can be used in laboratory research and development processes as well as in chemical and pharmaceutical synthesis. | | Chemical Properties | Dark green solid | | Synthesis | 6-Chloro-2-nitropyridin-3-amine (E-23) (8.8 g, 51 mmol, 1.0 eq.) was used as a raw material and mixed with Ruanne nickel (0.88 g) in methanol (100 mL). The reaction mixture was stirred at room temperature for 24 hours under hydrogen atmosphere. Upon completion of the reaction, the catalyst was removed by filtration and the filtrate was concentrated under vacuum to afford the target product 6-chloropyridine-2,3-diamine (E-24) (7 g, 95.6% yield) as a pale white solid. The product was detected by ESI-MS, m/z: 144.05 [M + H]+. | | References | [1] Patent: WO2011/149937, 2011, A1. Location in patent: Page/Page column 40; 41; 84
[2] Patent: WO2013/78441, 2013, A1. Location in patent: Paragraph 00143; 00326
[3] Patent: WO2014/151147, 2014, A1. Location in patent: Paragraph 00641
[4] Patent: US2015/30588, 2015, A1. Location in patent: Page/Page column 66
[5] Patent: US9295673, 2016, B2. Location in patent: Page/Page column 341; 342 |
| | 6-Chloro-2,3-diaminopyridine Preparation Products And Raw materials |
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