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2',3',5'-Tri-O-acetyl-2-aMino-6-chloropurine Riboside

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2',3',5'-Tri-O-acetyl-2-aMino-6-chloropurine Riboside manufacturers
2',3',5'-Tri-O-acetyl-2-aMino-6-chloropurine Riboside Basic information
Product Name:2',3',5'-Tri-O-acetyl-2-aMino-6-chloropurine Riboside
Synonyms:(2R,3R,4R,5R)-2-(AcetoxyMethyl)-5-(2-aMino-6-chloro-9H-purin-9-yl)tetrahydrofuran-3,4-diyl diacetate;2-AMino-6-chloropurine-9-(2',3',5'-tri-O-acetyl)-riboside;-[2,3,5-TRI-O-ACETYL-BETA-D-RIBOFURANOSYL]-2,6-DICHLOROPURINE;(2R,3R,4R,5R)-2-(Acetoxymethyl)-5-(2-amino-6-chloro-9H-purin-9-yl)tetrahydrofuran-3,4-diyl diacet;2-AMino-6-chloro-9-(2',3',5'-tri-O-acetyl-beta-D-ribofuranosyl)-9H-purine;2-Amino-6-chloropurine ribonucleoside triacetate;(2R,3R,4R,5R)-2-(Acetoxymethyl)-5-(2-amino-6-chloro-9H-purin-9-yl)tetrahydrofuran-3,4-diyl dia;9H-PURIN-2-AMINE,6-CHLORO-9-(2,3,5-TRI-O-ACETYL-B-D-RIBOFURANOSYL)-
CAS:16321-99-6
MF:C16H18ClN5O7
MW:427.8
EINECS:
Product Categories:Bases & Related Reagents;Nucleotides
Mol File:16321-99-6.mol
2',3',5'-Tri-O-acetyl-2-aMino-6-chloropurine Riboside Structure
2',3',5'-Tri-O-acetyl-2-aMino-6-chloropurine Riboside Chemical Properties
Melting point 146.0 to 150.0 °C
Boiling point 637.0±65.0 °C(Predicted)
density 1.70±0.1 g/cm3(Predicted)
storage temp. Refrigerator
solubility DMSO, Methanol
form Solid
pka1.69±0.10(Predicted)
color Pale Green
InChIKeyHLVGVJFVAKPFOZ-GNVCDDJRNA-N
SMILES[C@H]1(O[C@H](COC(=O)C)[C@@H](OC(=O)C)[C@H]1OC(=O)C)N1C=NC2C(Cl)=NC(N)=NC1=2 |&1:0,2,8,13,r|
Safety Information
HS Code 2933599590
MSDS Information
2',3',5'-Tri-O-acetyl-2-aMino-6-chloropurine Riboside Usage And Synthesis
Chemical PropertiesPale Green Solid
Uses2′,3′,5′-Tri-O-acetyl-6-chloroguanosine diacetate is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].
References[1] Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88. DOI:10.2174/138161212801227005
Tag:2',3',5'-Tri-O-acetyl-2-aMino-6-chloropurine Riboside(16321-99-6) Related Product Information
6-Chloro-9-(5-deoxy-D-ribofuranosyl)purine 2-Amino-9-(2-O-methyl-beta-D-ribofuranosyl)purine 2-Acetamido-6-chloro-9-(2',3',5'-tri-O-acetyl-beta-D-ribofuranosyl)purine 2-Amino-6-chloro-9-(beta-D-2-deoxyribofuranosyl)purine 6-Chloropurine-2'-deoxyriboside 2-Amino-6-chloropurine Riboside 6-Chloropurine 6-Chloroguanine 2-Aminopurine 6-Chloropurine ribonucleoside 2',3',5'-Tri-O-acetyl-2-aMino-6-chloropurine Riboside