- Columbin
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- $30.00
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2026-06-15
- CAS:546-97-4
- Purity: 99.76%
- Supply Ability: 10g
- Columbin
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2023-02-24
- CAS:546-97-4
- Min. Order: 5mg
- Purity: ≥98%(HPLC)
- Supply Ability: 10 g
- (1R,2S,3S,5S,8R,11R,12R)-5-(3-Furyl)-12-hydroxy-3,11-dimethyl-6,14-dioxatetracyclo[10.2.2.02,11.03,8]hexadec-15-ene-7,13-dione
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![(1R,2S,3S,5S,8R,11R,12R)-5-(3-Furyl)-12-hydroxy-3,11-dimethyl-6,14-dioxatetracyclo[10.2.2.0<sup>2,11</sup>.0<sup>3,8</sup>]hexadec-15-ene-7,13-dione pictures](https://img.chemicalbook.com/ProductImageEN/2020-1/Small/8bc99468-0952-462c-b2a2-9c76546d4ce8.jpg)
- $9.80
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2020-01-10
- CAS:546-97-4
- Min. Order: 1KG
- Purity: ≥98%
- Supply Ability: 20 tons
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| | Columbin Basic information |
| Product Name: | Columbin | | Synonyms: | (1s,2s,3s,5s,8r,11r,12s)-5-(3-furyl)-12-hydroxy-3,11-dimethyl-6,14-dioxatetracyclo[10.2.2.02,11.03,8]hexadec-15-ene-7,13-dione;Columbin, 98%, from limacia sagittata;(1R,4R,4aR,6aR,9S,10aS,10bS)-9-(3-Furanyl)-1,4,4a,5,6,6a,9,10,10a,10b-decahydro-4-hydroxy-4a,10a-dimethyl-1,4-etheno-3H,7H-benzo[1,2-c:3,4-c']dipyran-3,7-dione;(1R,4R,4aR,6aR,9S,10aS,10bS)-9-(3-Furanyl)decahydro-4-hydroxy-4a,10a-dimethyl-1,4-etheno-3H,7H-benzo[1,2-c:3,4-c']dipyran-3,7-dione;Tinosporin;(1R,2S,3S,5S,8R,11R,12R)-5-(3-Furyl)-12-hydroxy-3,11-dimethyl-6,14-dioxatetracyclo[10.2.2.02,11.03,8]hexadec-15-ene-7,13-dione;(1R,2S,3S,5S,8R,11R,12R)-5-(3-Furyl)-12-hydroxy-3,11-dimethyl-6,14-dioxatetracyclo[10.2.2.02,11.03,8]hexadec-15-ene-7,13-dione;1,4-Etheno-3H,7H-benzo[1,2-c:3,4-c']dipyran-3,7-dione, 9-(3-furanyl)-1,4,4a,5,6,6a,9,10,10a,10b-decahydro-4-hydroxy-4a,10a-dimethyl-, (1R,4R,4aR,6aR,9S,10aS,10bS)- | | CAS: | 546-97-4 | | MF: | C20H22O6 | | MW: | 358.39 | | EINECS: | | | Product Categories: | Miscellaneous Natural Products | | Mol File: | 546-97-4.mol |  |
| | Columbin Chemical Properties |
| Melting point | 190-191℃ | | alpha | D +52.5° (pyridine) | | Boiling point | 410.82°C (rough estimate) | | density | 1.36 | | refractive index | 1.4450 (estimate) | | storage temp. | -20°C | | solubility | DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 0.03 mg/ml | | pka | 12.14±0.70(Predicted) | | form | Cryst. | | color | White to off-white | | Major Application | metabolomics
vitamins, nutraceuticals, and natural products | | InChIKey | AALLCALQGXXWNA-QJNFORGASA-N | | SMILES | C1(=O)O[C@H](C2C=COC=2)C[C@@]2(C)[C@@]3([H])[C@@](C)(CC[C@@]12[H])[C@]1(O)C=C[C@@]3([H])OC1=O |
| WGK Germany | 3 | | HS Code | 29322090 | | Storage Class | 11 - Combustible Solids |
| | Columbin Usage And Synthesis |
| Chemical Properties | White needle-shaped crystals, easily soluble in methanol and ethyl acetate, almost insoluble in water, derived from Jin Guolan. | | Uses | Columbin is a furanolactone diterpene isolated from the roots of Jateorhiza and Tinospora species and is used in Asian and African folk medicine for analgesic and antipyretic properties. | | Definition | ChEBI: Columbin is an organic heterotricyclic compound and an organooxygen compound. | | in vivo | Columbin inhibits oedema formation in mice paw. At doses of 300 mg/kg and 700 mg/kg, columbin inhibits inflammation from 0 to 5 h and the results are comparable to that of aspirin as a standard anti-inflammatory drug. The inhibitory effect of columbin on carrageenan induced paw oedema in mice may be due to the suppression of the release of mediators responsible for inflammation including prostaglandin[1]. Columbin is poorly bioavailable (2.8% p.o. and 14% i.p.) in rats, but its transport is rapid across the Caco-2 cell monolayers, suggesting that extensive first-pass metabolism in the liver is the likely reason for its poor bioavailability[2]. | | IC 50 | Trypanosoma; COX-2: 53.1 μM (EC50); COX-1: 327 μM (EC50) |
| | Columbin Preparation Products And Raw materials |
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