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Columbin

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Company Name: Shanghai Zheyan Biotech Co., Ltd.
Tel: 18017610038
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Products Intro: Product Name:Columbin
CAS:546-97-4
Purity:HPLC>=98% Package:20mg
Company Name: Chengdu GLP biotechnology Co Ltd
Tel: 028-87075086 13350802083
Email: scglp@glp-china.com
Products Intro: Product Name:Columbin
CAS:546-97-4
Purity:0.98 Package:20MG;50MG;100MG;1G;5G;1KG
Company Name: Chengdu Biopurify Phytochemicals Ltd.
Tel: +86-28-82633860; +8618080483897
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Products Intro: Product Name:Columbin
CAS:546-97-4
Purity:0.98 Package:10mg;20mg;50mg;100mg
Company Name: Hubei Jusheng Technology Co.,Ltd.
Tel: 18871490254
Email: linda@hubeijusheng.com
Products Intro: Product Name:(1R,2S,3S,5S,8R,11R,12R)-5-(3-Furyl)-12-hydroxy-3,11-dimethyl-6,14-dioxatetracyclo[10.2.2.02,11.03,8]hexadec-15-ene-7,13-dione
CAS:546-97-4
Purity:0.99 Package:5KG;1KG Remarks:C20H22O6
Company Name: Shanghai Standard Technology Co., Ltd.
Tel: 18502101150
Email: ft-sales@nature-standard.com
Products Intro: Product Name:Columbin
CAS:546-97-4
Purity:>=98%(HPLC) Package:20mg;USD

Columbin manufacturers

  • Columbin
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  • $30.00 / 5mg
  • 2025-05-26
  • CAS:546-97-4
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  • Purity: 99.34%
  • Supply Ability: 10g
  • Columbin
  • Columbin pictures
  • $0.00 / 20mg
  • 2023-02-24
  • CAS:546-97-4
  • Min. Order: 5mg
  • Purity: ≥98%(HPLC)
  • Supply Ability: 10 g
Columbin Basic information
Product Name:Columbin
Synonyms:(1s,2s,3s,5s,8r,11r,12s)-5-(3-furyl)-12-hydroxy-3,11-dimethyl-6,14-dioxatetracyclo[10.2.2.02,11.03,8]hexadec-15-ene-7,13-dione;Columbin, 98%, from limacia sagittata;(1R,4R,4aR,6aR,9S,10aS,10bS)-9-(3-Furanyl)-1,4,4a,5,6,6a,9,10,10a,10b-decahydro-4-hydroxy-4a,10a-dimethyl-1,4-etheno-3H,7H-benzo[1,2-c:3,4-c']dipyran-3,7-dione;(1R,4R,4aR,6aR,9S,10aS,10bS)-9-(3-Furanyl)decahydro-4-hydroxy-4a,10a-dimethyl-1,4-etheno-3H,7H-benzo[1,2-c:3,4-c']dipyran-3,7-dione;Tinosporin;(1R,2S,3S,5S,8R,11R,12R)-5-(3-Furyl)-12-hydroxy-3,11-dimethyl-6,14-dioxatetracyclo[10.2.2.02,11.03,8]hexadec-15-ene-7,13-dione;(1R,2S,3S,5S,8R,11R,12R)-5-(3-Furyl)-12-hydroxy-3,11-dimethyl-6,14-dioxatetracyclo[10.2.2.02,11.03,8]hexadec-15-ene-7,13-dione;1,4-Etheno-3H,7H-benzo[1,2-c:3,4-c']dipyran-3,7-dione, 9-(3-furanyl)-1,4,4a,5,6,6a,9,10,10a,10b-decahydro-4-hydroxy-4a,10a-dimethyl-, (1R,4R,4aR,6aR,9S,10aS,10bS)-
CAS:546-97-4
MF:C20H22O6
MW:358.39
EINECS:
Product Categories:Miscellaneous Natural Products
Mol File:546-97-4.mol
Columbin Structure
Columbin Chemical Properties
Melting point 190-191℃
alpha D +52.5° (pyridine)
Boiling point 410.82°C (rough estimate)
density 1.36
refractive index 1.4450 (estimate)
storage temp. -20°C
solubility DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 0.03 mg/ml
pka12.14±0.70(Predicted)
form Cryst.
color White to off-white
Safety Information
WGK Germany 3
HS Code 29322090
MSDS Information
Columbin Usage And Synthesis
UsesColumbin is a furanolactone diterpene isolated from the roots of Jateorhiza and Tinospora species and is used in Asian and African folk medicine for analgesic and antipyretic properties.
DefinitionChEBI: Columbin is an organic heterotricyclic compound and an organooxygen compound.
in vivo

Columbin inhibits oedema formation in mice paw. At doses of 300 mg/kg and 700 mg/kg, columbin inhibits inflammation from 0 to 5 h and the results are comparable to that of aspirin as a standard anti-inflammatory drug. The inhibitory effect of columbin on carrageenan induced paw oedema in mice may be due to the suppression of the release of mediators responsible for inflammation including prostaglandin[1]. Columbin is poorly bioavailable (2.8% p.o. and 14% i.p.) in rats, but its transport is rapid across the Caco-2 cell monolayers, suggesting that extensive first-pass metabolism in the liver is the likely reason for its poor bioavailability[2].

IC 50Trypanosoma; COX-2: 53.1 μM (EC50); COX-1: 327 μM (EC50)
Columbin Preparation Products And Raw materials
Preparation ProductsISOCOLUMBIN
Tag:Columbin(546-97-4) Related Product Information
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