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| | DEMETON Basic information |
| | DEMETON Chemical Properties |
| Boiling point | bp2 134° | | density | 1.1183 g/cm3 (20℃) | | refractive index | 1.4875 (589.3 nm 20℃) | | solubility | Chloroform (Sparingly), Ethyl Acetate (Slightly), Methanol (Slightly) | | form | Pale yellow to light brown,
oily liquid | | Henry's Law Constant | 5.5×101 mol/(m3Pa) at 25℃, HSDB (2015) | | Exposure limits | ACGIH:TLV-TWA 0.05 mg/m3,Inhalable Aerosol and Vapor (0.005 ppm)
OSHA:PEL-TWA 0.1 mg/m3
NIOSH:REL-TWA 0.1 mg/m3 | | EPA Substance Registry System | Demeton (8065-48-3) |
| Hazard Codes | T+,N | | Risk Statements | 27/28-50 | | Safety Statements | 28-36/37-45-61 | | RIDADR | 3018 | | OEB | D | | OEL | TWA: 0.1 mg/m3 [skin] | | RTECS | TF3150000 | | HazardClass | 6.1(a) | | PackingGroup | I | | HS Code | 29309090 | | Hazardous Substances Data | 8065-48-3(Hazardous Substances Data) | | Toxicity | LD50 in female, male rats (mg/kg): 2.5, 6.2 orally; 8.2, 14 dermally (Gaines) | | IDLH | 10 mg/m3 |
| | DEMETON Usage And Synthesis |
| Description | Demeton is an organophosphate insecticide. It has a moderate aqueous solubility and is highly volatile. There are considerable gaps in literature regarding its environmental fate. Demeton is highly toxic to mammals, is a neurotoxin and may adversely affect reproduction and/or development. It is also an acetyl cholinesterase inhibitor. It is highly toxic to birds and aquatic invertebrates. It moderately toxic to fish and honeybees. | | Chemical Properties | Demeton is a light brown liquid with an odor
of sulfur compounds; freezing/melting point ≤‐13
C | | Uses | Insecticide. | | Uses | Acaricide; insecticide | | Production Methods | Demeton is commercially produced by reacting O,O-diethyl phosphorochloridothioate with 2-(ethylthio)ethanol to form the organophosphorothioate ester. The synthesis begins with the preparation of O,O-diethyl phosphorochloridothioate, which is then subjected to nucleophilic substitution with 2-(ethylthio)ethanol under controlled conditions, typically in an organic solvent such as toluene or acetone. A base like triethylamine is used to neutralise the hydrochloric acid byproduct and drive the reaction forward. The resulting product is a mixture of Demeton-O and Demeton-S isomers, which may be further purified or used as a technical-grade mixture. | | General Description | Oily liquid with an amber color and an odor of sulfur. Used as an agricultural insecticide. | | Reactivity Profile | DEMETON may release sulfur oxides and phosphoric acid. Solvent carrier vapors may travel on ground to ignition source. Avoid strong oxidizers. Avoid mixtures with water or polar solvents, in which sulfur is lost to oxygen, air and light, which cause hydrolysis, alkaline mixtures and oxidizing agents. [EPA, 1998]. | | Health Hazard | DEMETON is a cholinesterase inhibitor. It is readily absorbed through the skinand is extremely toxic. Probable human lethal oral dose is 5-50 mg/kg or 7 drops to 1 teaspoonful for 150 lb. person. Acute dose is believed to be 12 to 20 mg by oral route. | | Health Hazard | One of the extremely toxic organophosphorus pesticides; cholinesterase inhibitor;exhibits acute, delayed, and chronic effects;toxic symptoms include headache, dizziness, muscle spasms, pinpoint pupils, blurredvision, weakness, abdominal pain, vomiting,nausea, diarrhea, and seizure; high exposuremay cause coma and death; other symptomsare chest pain, low or high blood pressure,shortness of breath, psychosis, respiratorydepression, and respiratory paralysis; readily absorbed through skin; effects may bedelayed by several hours; ingestion can causeimmediate seizure or loss of consciousness;probable oral lethal dose within the range0.4–2 g for adult humans.
LD50 oral (rat): 1.7 mg/kg
LD50 skin (rat): 8–14 mg/kg. | | Fire Hazard | May release sulfur oxides and phosphoric acid. Solvent carrier vapors may travel on ground to ignition source. Avoid strong oxidizers. Avoid mixtures with water or polar solvents, in which sulfur is lost to oxygen, air and light, which cause hydrolysis, alkaline mixtures and oxidizing agents. | | Mechanism of action | Systemic with contact and stomach action. Acetylcholinesterase (AChE) inhibitor. | | Potential Exposure | A potential danger to those involved
in the manufacture, formulation, and application of this
systemic insecticide and acaricide. | | Shipping | UN3278 Organophosphorus compound, liquid,
toxic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous
materials, Hazard Technical Name Required, Potential
Inhalation Hazard (Special Provision 5). UN3017
Organophosphorus pesticides, liquid, toxic, flammable,
flash point not , 23
C, Hazard class: 6.1; Labels: 6.1-
Poisonous materials, 3-Flammable liquid. UN2810 Toxic
liquids, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1-
Poisonous materials, Technical Name Required. | | Incompatibilities | May form explosive mixture with air.
Strong oxidizers, strong bases, soluble mercury, other
pesticides, and water. | | Waste Disposal | The thiono-and thiolo-isomers of
this mixture are 50% hydrolyzed in 75 minutes and 0.85 min-
ute, respectively @ 20℃
and pH 13. At pH 9 and 70 ℃
, the
half-life of Demeton is 1.25 hour, but an pH 1-5 it is over
11 hours. Sand and rushed limestone may be added together
with a flammable solvent; the resultant mixture may be burned
in a furnace with afterburner and alkaline scrubber
.In
accordance with 40CFR165, follow recommendations for the
disposal of pesticides and pesticide containers. Must be dis-
posed properly by following package label directions or by
contacting your local or federal environmental control agency,
or by contacting your regional EPA office. | | Pesticide Type | Insecticide; Acaricide |
| | DEMETON Preparation Products And Raw materials |
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