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| | 4-Bromo-1-chloro-2-(4-ethoxybenzyl)benzene Basic information |
| | 4-Bromo-1-chloro-2-(4-ethoxybenzyl)benzene Chemical Properties |
| Boiling point | 393.0±32.0 °C(Predicted) | | density | 1.371±0.06 g/cm3(Predicted) | | storage temp. | Sealed in dry,Room Temperature | | solubility | Acetonitrile (Slightly), DMSO (Slightly), Methanol (Slightly) | | form | Low-Melting Solid | | color | White to Off-White | | Stability: | Stable under recommended storage conditions., Stable Under Recommended Storage C | | InChI | InChI=1S/C15H14BrClO/c1-2-18-14-6-3-11(4-7-14)9-12-10-13(16)5-8-15(12)17/h3-8,10H,2,9H2,1H3 | | InChIKey | ZUNCHZBITMUSRD-UHFFFAOYSA-N | | SMILES | C1(Cl)=CC=C(Br)C=C1CC1=CC=C(OCC)C=C1 |
| | 4-Bromo-1-chloro-2-(4-ethoxybenzyl)benzene Usage And Synthesis |
| Uses | 5-Bromo-2-chloro-4'-ethoxydiphenylmethane is a hydrocarbon derivative and can be used as an intermediate for dapagliflozin. | | Synthesis | Oxalyl chloride (0.8 mL) was added to a solution of 5-bromo-2-chlorobenzoic acid (2 g) in dichloromethane (20 mL) and dimethylformamide (0.2 mL) under a nitrogen atmosphere. The reaction mixture was stirred for one hour at 25° C to 30° C. After completion of the reaction, the reaction mixture was concentrated under a vacuum at 40° C to 45° C. to obtain an oily residue. The oily residue was dissolved in dichloromethane (20 mL) and cooled to 0° C. To this solution, phenol (1.1 mL) and aluminium chloride (2.3 g) were added at 0° C. to 5° C. The reaction mixture was stirred at 0° C to 5° C for 2 hours. The reaction mixture was allowed to warm to about 20° C, and triethylsilane (3.4 mL) was slowly added to it at the same temperature. The reaction mixture was stirred for about 36 hours from 20° C to 25° C. After completion of the reaction, 4-bromo-1-chloro-2-(4-ethoxybenzyl)benzene was obtained by further purification.
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| | 4-Bromo-1-chloro-2-(4-ethoxybenzyl)benzene Preparation Products And Raw materials |
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