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N-[3-Chloro-4-(3-fluorobenzyloxy)phenyl]-6-iodoquinazolin-4-amine

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N-[3-Chloro-4-(3-fluorobenzyloxy)phenyl]-6-iodoquinazolin-4-amine manufacturers
N-[3-Chloro-4-(3-fluorobenzyloxy)phenyl]-6-iodoquinazolin-4-amine Basic information
Product Name:N-[3-Chloro-4-(3-fluorobenzyloxy)phenyl]-6-iodoquinazolin-4-amine
Synonyms:N-[3-Chloro-4-(3-fluorobenzyloxy)-phenyl]-6-iodoquinazolin-4-amine;N-{3-Chloro-4-[(3-fluorophenyl)-methoxy]-phenyl}-6-iodo-4-quinazolinamine;6-Iodo-4-[3-chloro-4-(3-fluorobenzyloxy)anilino]quinazoline;N-[3-Chloro-4-(3-fluorobenzyloxy) phenyl]-6-iodoquinazolin-5-amine;4-[3-Chloro-4-(3-fluorobenzyloxy)phenylamino]-6-iodoquinazolin;N-(3-Chloro-4-((3-fluorobenzyl);Lapatinib Impurity 25;N-{3-chloro-4-[(3-fluorobenzyl)oxy]phenyl}-6-iodo-4-quinazolinamine
CAS:231278-20-9
MF:C21H14ClFIN3O
MW:505.71
EINECS:607-200-2
Product Categories:Lapatinib;Intermediates;Intermediates & Fine Chemicals;Pharmaceuticals;Pharmaceutical intermediate;Various Intermediates;Intermediate of lapatinib ditosylate
Mol File:231278-20-9.mol
N-[3-Chloro-4-(3-fluorobenzyloxy)phenyl]-6-iodoquinazolin-4-amine Structure
N-[3-Chloro-4-(3-fluorobenzyloxy)phenyl]-6-iodoquinazolin-4-amine Chemical Properties
Melting point 222-224°C
Boiling point 581.3±50.0 °C(Predicted)
density 1.691±0.06 g/cm3(Predicted)
storage temp. Keep in dark place,Inert atmosphere,Room temperature
solubility DMSO (Slightly), Methanol (Slightly, Heated)
pka5.04±0.50(Predicted)
form Solid
color Yellow to Dark Yellow
Water Solubility Slightly soluble in water.
Sensitive Light Sensitive
InChIInChI=1S/C21H14ClFIN3O/c22-18-10-16(5-7-20(18)28-11-13-2-1-3-14(23)8-13)27-21-17-9-15(24)4-6-19(17)25-12-26-21/h1-10,12H,11H2,(H,25,26,27)
InChIKeyUHFPFDMMKYQMLC-UHFFFAOYSA-N
SMILESN1=C2C(C=C(I)C=C2)=C(NC2=CC=C(OCC3=CC=CC(F)=C3)C(Cl)=C2)N=C1
CAS DataBase Reference231278-20-9(CAS DataBase Reference)
Safety Information
HS Code 2933.59.8000
MSDS Information
N-[3-Chloro-4-(3-fluorobenzyloxy)phenyl]-6-iodoquinazolin-4-amine Usage And Synthesis
DescriptionN-[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-iodo-quinazolin-4-amine is a quinazoline derivative that has also been used in the design, synthesis and biological evaluation of quinazoline-phosphoramidate mustard conjugates as anticancer drugs.
Chemical PropertiesYellow Solid
UsesLapatinib intermediate
Uses4-[3-Chloro-4-(3-fluorobenzyloxy)phenylamino]-6-iodoquinazoline is used as an organic chemical synthesis intermediate.
N-[3-Chloro-4-(3-fluorobenzyloxy)phenyl]-6-iodoquinazolin-4-amine Preparation Products And Raw materials
Tag:N-[3-Chloro-4-(3-fluorobenzyloxy)phenyl]-6-iodoquinazolin-4-amine(231278-20-9) Related Product Information
4-Methoxyphenylacetone Diphenyldiethoxysilane 4-Methoxybenzylchloride Sulfaquinoxaline Bis(2-ethylhexyl)amine Quinazoline Diphenyldimethoxysilane Triallylamine Triethanolamine Quinoxaline Diphenyl ether Phenyl valerate Triethylamine 6,7-Bis-(2-methoxyethoxy)-4(3H)-quinazolinone Phenyl resin Lapatinib 3-Chloro-4-(3-fluorobenzyloxy)aniline Phenylacetic acid