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| | 6-Chloro-3-oxo-2,3-dihydropyridazine-4-carboxylic acid Basic information |
| Product Name: | 6-Chloro-3-oxo-2,3-dihydropyridazine-4-carboxylic acid | | Synonyms: | 6-chloro-3-hydroxypyridazine-4-carboxylicacid;4-Pyridazinecarboxylic acid, 6-chloro-2,3-dihydro-3-oxo-;3-chloro-6-oxo-1H-pyridazine-5-carboxylicaci;6-CHLORO-3-OXO-2,3-DIHYDROPYRIDAZINE-4-CARBOXYLIC ACID ISO 9001：2015 REACH;3-chloro-6-oxo-1H-pyridazine-5-carboxylic acid | | CAS: | 50681-26-0 | | MF: | C5H3ClN2O3 | | MW: | 174.54 | | EINECS: | | | Product Categories: | | | Mol File: | 50681-26-0.mol |  |
| | 6-Chloro-3-oxo-2,3-dihydropyridazine-4-carboxylic acid Chemical Properties |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C | | Appearance | White to off-white Solid |
| | 6-Chloro-3-oxo-2,3-dihydropyridazine-4-carboxylic acid Usage And Synthesis |
| Uses | 6-Chloro-3-hydroxypyridazine-4-carboxylic acid | | Synthesis | A. Methyl 3,6-dichloropyridazine-4-carboxylate (2.00 g, 10.4 mmol) was dissolved in dioxane (9.0 mL) and 1M hydrochloric acid solution (10.4 mL) was added. The reaction mixture was stirred at 90°C for 20 hours. After completion of the reaction, the mixture was cooled to 0 °C and the precipitate was collected by filtration. The precipitate was washed with cold water followed by a small amount of pyridazine acid Z.1 to afford the target product 3-oxo-6-chloro-2,3-dihydropyridazine-4-carboxylic acid (955 mg, 53% yield). The product was confirmed by HPLC-MS analysis (MS (MH)+ = 173; retention time t Ret = 0.00min; analytical method: LCMSBAS1). | | References | [1] Patent: WO2011/131741, 2011, A1. Location in patent: Page/Page column 62-63
[2] Patent: WO2011/144622, 2011, A1. Location in patent: Page/Page column 55
[3] Patent: US2012/94976, 2012, A1. Location in patent: Page/Page column 33-34 |
| | 6-Chloro-3-oxo-2,3-dihydropyridazine-4-carboxylic acid Preparation Products And Raw materials |
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