- 6-Chloropyridazin-3-ol
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- $1.10 / 1g
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2025-11-18
- CAS:19064-67-6
- Min. Order: 1g
- Purity: 99.00%
- Supply Ability: 100 Tons Min
- 6-Chloro-3-hydroxypyridazine
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- $200.00 / 1KG
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2025-09-25
- CAS:19064-67-6
- Min. Order: 1KG
- Purity: 99%, 99.5% Sublimated
- Supply Ability: g-kg-tons, free sample is available
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| | 6-Chloropyridazin-3-ol Basic information | | Uses |
| Product Name: | 6-Chloropyridazin-3-ol | | Synonyms: | 3-Chloro-6-hydroxypyridazine;6-Chloropyridazin-3-ol;6-Chloropyridazin-3(2H)-one;6-Chloropyridazine-3-ol;6-Chloro-3-hydroxypyridazine;6-Chloro-3-hydroxypyridaz...;3(2H)-pyridazinone, 6-chloro-;3-Chloro-6-pyridazone | | CAS: | 19064-67-6 | | MF: | C4H3ClN2O | | MW: | 130.53 | | EINECS: | | | Product Categories: | | | Mol File: | 19064-67-6.mol |  |
| | 6-Chloropyridazin-3-ol Chemical Properties |
| Melting point | 140.0 to 144.0 °C | | density | 1.55±0.1 g/cm3(Predicted) | | storage temp. | Keep in dark place,Sealed in dry,Room Temperature | | solubility | soluble in Methanol | | pka | 9.80±0.40(Predicted) | | form | powder to crystal | | color | White to Almost white | | InChI | InChI=1S/C4H3ClN2O/c5-3-1-2-4(8)7-6-3/h1-2H,(H,7,8) | | InChIKey | YICPBKWYZXFJNB-UHFFFAOYSA-N | | SMILES | C1(=O)NN=C(Cl)C=C1 |
| Hazard Codes | Xn | | Risk Statements | 22 | | HazardClass | IRRITANT | | HS Code | 2933998090 | | Storage Class | 11 - Combustible Solids | | Hazard Classifications | Acute Tox. 4 Oral |
| | 6-Chloropyridazin-3-ol Usage And Synthesis |
| Uses | 6-Chloropyridazin-3(2h)-one (cas# 19064-67-6) is a useful research chemical. | | Uses | 6-Chloropyridazin-3-ol is a white to almost white powder or crystal, which can be used as a raw material for organic synthesis or as a pharmaceutical intermediate. | | Synthesis | General procedure for the synthesis of 3-hydroxy-6-chloropyridazine from 3,6-dichloropyridazine: to a solution of acetic acid/water (5:1, 20 mL) of 3,6-dichloropyridazine (1 g, 0.006759 mol) was added potassium acetate (0.662 g, 0.006759 mol), and the mixture was heated to 140 °C under microwave conditions for 70 min. After completion of the reaction, the reaction flask was cooled and the solvent was removed by vacuum evaporation. Ethyl acetate and water were added to the residue, the layers were separated and the aqueous layer was extracted with ethyl acetate. The organic phases were combined, washed with saturated brine, dried over anhydrous sodium sulfate and concentrated to give 6-chloro-2H-pyridazin-3-one (0.813 g, 92.5% yield). The product was characterized by 1H NMR (CDCl3): δ 6.96 (d, 1H), 7.25 (d, 1H). | | References | [1] Organic and Biomolecular Chemistry, 2008, vol. 6, # 1, p. 175 - 186
[2] Bioorganic and Medicinal Chemistry, 2017, vol. 25, # 14, p. 3649 - 3657
[3] Organic Letters, 2011, vol. 13, # 2, p. 272 - 275
[4] Bioorganic and Medicinal Chemistry Letters, 2012, vol. 22, # 2, p. 1226 - 1229
[5] Patent: WO2007/8144, 2007, A1. Location in patent: Page/Page column 31 |
| | 6-Chloropyridazin-3-ol Preparation Products And Raw materials |
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