ETHYL 1-METHYL-3-PHENYL-1H-PYRAZOLE-5-CARBOXYLATE

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ETHYL 1-METHYL-3-PHENYL-1H-PYRAZOLE-5-CARBOXYLATE manufacturers
ETHYL 1-METHYL-3-PHENYL-1H-PYRAZOLE-5-CARBOXYLATE Basic information
Product Name:ETHYL 1-METHYL-3-PHENYL-1H-PYRAZOLE-5-CARBOXYLATE
Synonyms:Ethyl 1-methyl-3-phenyl-1H-pyrazole-5-carboxylate 97%;5-(Ethoxycarbonyl)-1-methyl-3-phenyl-1H-pyrazole, 1-[5-(Ethoxycarbonyl)-1-methyl-1H-pyrazol-3-yl]benzene;Ethyl 1-Methyl-3-phenylpyrazole-5-carboxylate;1H-Pyrazole-5-carboxylic acid, 1-methyl-3-phenyl-, ethyl ester;1H-Pyrazole-5-carboxylic acid, 1;SALOR-INT L201367-1EA;ETHYL 1-METHYL-3-PHENYL-1H-PYRAZOLE-5-CARBOXYLATE;JR-13855, Ethyl 1-methyl-3-phenyl-1H-pyrazole-5-carboxylate, 95%
CAS:10250-63-2
MF:C13H14N2O2
MW:230.26
EINECS:
Product Categories:
Mol File:10250-63-2.mol
ETHYL 1-METHYL-3-PHENYL-1H-PYRAZOLE-5-CARBOXYLATE Structure
ETHYL 1-METHYL-3-PHENYL-1H-PYRAZOLE-5-CARBOXYLATE Chemical Properties
Melting point 27 °C
Boiling point 380.6±30.0 °C(Predicted)
density 1.13±0.1 g/cm3(Predicted)
storage temp. Sealed in dry,Room Temperature
pka0.04±0.10(Predicted)
Safety Information
Hazard Note Harmful
HS Code 2933199090
MSDS Information
ETHYL 1-METHYL-3-PHENYL-1H-PYRAZOLE-5-CARBOXYLATE Usage And Synthesis
Synthesis
ETHYL 2,4-DIOXO-4-PHENYLBUTANOATE

6296-54-4

Methylhydrazine sulfate

302-15-8

ETHYL 1-METHYL-3-PHENYL-1H-PYRAZOLE-5-CARBOXYLATE

10250-63-2

To a solution of ethyl 2,4-dioxo-4-phenylbutyrate (1.0 g, 4.5 mmol), methylhydrazine sulfate (1.0 g, 6.8 mmol) and sodium hydroxide (0.5 g, 13.6 mmol) in ethanol (50 mL) was added the reaction mixture. The reaction mixture was stirred at 70 °C overnight. After completion of the reaction, the reaction was quenched with ice water (100 mL), extracted with ethyl acetate, the organic phase was washed with brine, dried over anhydrous sodium sulfate, filtered and concentrated to give the crude product. The crude product was purified by silica gel column chromatography eluting with appropriate eluent to give ethyl 1-methyl-3-phenyl-1H-pyrazole-5-carboxylate (247.5 mg, 23.9%). Mass spectrum (ESI) m/z: 231.1 [M + 1].

References[1] Patent: US2018/271846, 2018, A1. Location in patent: Paragraph 0176; 0178; 0179
ETHYL 1-METHYL-3-PHENYL-1H-PYRAZOLE-5-CARBOXYLATE Preparation Products And Raw materials
Raw materials5-PHENYL-PYRAZOLE-3-CARBOXYLIC ACID ETHYL ESTER-->ETHYL 2,4-DIOXO-4-PHENYLBUTANOATE-->Methylhydrazine-->Methylhydrazine sulfate-->Iodomethane-->Ethanol-->Sodium hydroxide
Preparation Products1-METHYL-3-PHENYL-1H-PYRAZOLE-5-CARBOXYLIC ACID
Tag:ETHYL 1-METHYL-3-PHENYL-1H-PYRAZOLE-5-CARBOXYLATE(10250-63-2) Related Product Information
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