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| | Hepcidin-25 (trifluoroacetate salt) Basic information |
| | Hepcidin-25 (trifluoroacetate salt) Chemical Properties |
| solubility | Water: 1 mg/ml |
| | Hepcidin-25 (trifluoroacetate salt) Usage And Synthesis |
| Description | Hepcidin-25 is a peptide hormone that regulates iron homeostasis and has antibacterial activity.1 It is predominantly synthesized by hepatocytes and secreted into the circulation. Hepcidin-25 binds to ferroportin, a membrane-bound iron exporter expressed by macrophages, enterocytes, and hepatocytes, inducing ferroportin internalization and degradation, which increases intracellular iron levels and decreases dietary iron absorption and plasma iron levels. It is bactericidal against multidrug-resistant clinical isolates of Gram-negative and Gram-positive bacteria, including P. aeruginosa, E. coli, K. pneumoniae, S. aureus, S. epidermidis, and E. faecium, when used at concentrations ranging from 6.25 to 50 µg/ml.2 Serum hepcidin-25 levels are increased in patients with chronic kidney disease (CKD).3WARNING This product is not for human or veterinary use. | | References | [1] JOYCE J C KROOT. Hepcidin in human iron disorders: diagnostic implications.[J]. Clinical chemistry, 2011, 57 12: 1650-1669. DOI: 10.1373/clinchem.2009.140053
[2] GIUSEPPANTONIO MAISETTA . Antimicrobial activity of human hepcidin 20 and 25 against clinically relevant bacterial strains: Effect of copper and acidic pH[J]. Peptides, 2010, 31 11: Pages 1995-2002. DOI: 10.1016/j.peptides.2010.08.007
[3] KEN TSUCHIYA Kosaku N. Hepcidin is a potential regulator of iron status in chronic kidney disease.[J]. Therapeutic Apheresis and Dialysis, 2013, 17 1: 1-8. DOI: 10.1111/1744-9987.12001 |
| | Hepcidin-25 (trifluoroacetate salt) Preparation Products And Raw materials |
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