|
|
| | Ethyl bromodifluoroacetate Basic information |
| | Ethyl bromodifluoroacetate Chemical Properties |
| Boiling point | 112 °C/700 mmHg (lit.) | | density | 1.583 g/mL at 25 °C (lit.) | | refractive index | n20/D 1.387(lit.) | | Fp | 70 °F | | storage temp. | Keep in dark place,Inert atmosphere,Room temperature | | solubility | Soluble in most organic solvents. | | form | Liquid | | color | Clear colorless to slightly yellow | | Specific Gravity | 1.583 | | BRN | 1906095 | | InChI | InChI=1S/C4H5BrF2O2/c1-2-9-3(8)4(5,6)7/h2H2,1H3 | | InChIKey | IRSJDVYTJUCXRV-UHFFFAOYSA-N | | SMILES | C(OCC)(=O)C(Br)(F)F | | CAS DataBase Reference | 667-27-6(CAS DataBase Reference) | | NIST Chemistry Reference | Ethyl bromodifluoroacetate(667-27-6) |
| Hazard Codes | C,F,Xi | | Risk Statements | 10-34-36 | | Safety Statements | 26-36/37/39-45-16-27 | | RIDADR | UN 2924 3/PG 2 | | WGK Germany | 3 | | Hazard Note | Irritant/Flammable | | TSCA | No | | HazardClass | 3 | | PackingGroup | II | | HS Code | 29159000 | | Storage Class | 3 - Flammable liquids | | Hazard Classifications | Flam. Liq. 2
Skin Corr. 1B |
| | Ethyl bromodifluoroacetate Usage And Synthesis |
| Description | Ethyl bromodifluoroacetate, a clear to yellow liquid, is an ester of bromodifluoroacetic acid and ethyl alcohol. It is an ester that can be used to introduce the CF2 group when synthesizing chemical compounds. Ethyl bromdifluoroacetate is considered to be a good compound in the generation of compounds and for testing with other organic compounds like lactones, imines, and other amino acids.
| | Chemical Properties | clear colorless to slightly yellow liquid | | Uses | Ethyl bromodifluoroacetate is usually used in the preparation of substituted ethyl 2′-pyridyldifluoroacetates,4-alkoxymethyl- and 4-aryloxymethyl-3,3-difluoropiperidines,α,α-difluoro-β-lactams,mono- and difluoromethylated phenanthridine derivatives. | | Uses | Efficient difluoroalkylation of aryl boronic acids via palladium catalysis. Novel, moisture-stable bromodifluoromethylated phosphonate, ester, and amide. Efficient coupling with aryl boronic acids via Pd catalysis. A Cu-catalyzed regioselective bromodifluoroacetylation of alkenes, using ethyl bromodifluoroacetate (BrCF2CO2Et) as a difluoroacetylating reagent. | | Uses | Ethyl bromodifluoroacetate, is used for the treatment of the Reformat sky reagent with aldehydes and ketones affords 2,2-difluoro-3-hydroxy esters. It is also used in the analysis of reagent purity through IR, NMR. | | Preparation | Difluorobromoacetonitrile is taken as a raw material, and prepared through a one-pot method and subjected to alcoholysis and esterification in ethanol aqueous solution to obtain ethyl bromodifluoroacetate.Reaction equation is:
BrF2CCN→BrF2CCOOH→BrF2CCOOC2H5 |
| | Ethyl bromodifluoroacetate Preparation Products And Raw materials |
|