3-(3-Pyridinyl)benzoic acid manufacturers
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| | 3-(3-Pyridinyl)benzoic acid Basic information |
| | 3-(3-Pyridinyl)benzoic acid Chemical Properties |
| Melting point | 202-205.5 | | Boiling point | 420.1±28.0 °C(Predicted) | | density | 1.241±0.06 g/cm3(Predicted) | | storage temp. | Sealed in dry,Room Temperature | | form | solid | | pka | 3.78±0.10(Predicted) | | color | white | | CAS DataBase Reference | 4385-77-7(CAS DataBase Reference) |
| | 3-(3-Pyridinyl)benzoic acid Usage And Synthesis |
| Chemical Properties | White or off-white solid | | Synthesis | Example 163 A Synthesis of 3-(pyridin-3-yl)benzoic acid: 3-Carboxyphenylboronic acid (1.5 g, 9 mmol) and 3-bromopyridine (1.5 g, 9.9 mmol) were dissolved in a solvent mixture of acetonitrile (40 mL) and water (40 mL). Potassium carbonate (5.5 g, 40 mmol) and bis(triphenylphosphine)palladium(II) chloride (400 mg, 0.37 mmol) were subsequently added. The reaction mixture was stirred under reflux conditions overnight. Upon completion of the reaction, the suspension was filtered while hot and the filtrate was concentrated to half the original volume. The concentrated aqueous phase was washed with dichloromethane. Subsequently, the aqueous phase was adjusted to pH=3 with 1 M hydrochloric acid, the precipitated solid was filtered and washed with water. Finally, the solid residue was dried under vacuum to give 1.5 g of 3-(pyridin-3-yl)benzoic acid in 83% yield.LC-MS (ESI) m/z: 200 (M + 1)+. | | References | [1] Synlett, 2000, # 6, p. 829 - 831
[2] Patent: US2009/197863, 2009, A1. Location in patent: Page/Page column 76
[3] Journal of the American Chemical Society, 2013, vol. 135, # 5, p. 1853 - 1863
[4] Patent: JP5743418, 2015, B2. Location in patent: Paragraph 0142; 0143; 0144 |
| | 3-(3-Pyridinyl)benzoic acid Preparation Products And Raw materials |
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