- 3-Pyridyl bromide
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- $1.10
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2026-08-20
- CAS:626-55-1
- Min. Order: 1g
- Purity: 99.00%
- Supply Ability: 100 Tons min
- 3-Pyridyl bromide
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-
2026-06-30
- CAS:626-55-1
- Min. Order: 1KG
- Purity: 98.0%
- Supply Ability: 10000KGS
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| | 3-Pyridyl bromide Basic information |
| | 3-Pyridyl bromide Chemical Properties |
| Melting point | -27°C | | Boiling point | 173 °C (lit.) | | density | 1.64 g/mL at 25 °C (lit.) | | vapor pressure | 1.64hPa at 25℃ | | refractive index | n20/D 1.571(lit.) | | Fp | 125 °F | | storage temp. | Keep in dark place,Inert atmosphere,2-8°C | | solubility | 31g/l | | pka | 2.84(at 25℃) | | form | Liquid | | Specific Gravity | 1.617 | | color | Clear colorless to yellow or slightly brown | | Water Solubility | Soluble in water (31 g/L at 20°C). | | BRN | 105880 | | Henry's Law Constant | 8.3×10-1 mol/(m3Pa) at 25℃, Ebert et al. (2023) | | Dielectric constant | 9.8499999999999996 | | InChI | 1S/C5H4BrN/c6-5-2-1-3-7-4-5/h1-4H | | InChIKey | NYPYPOZNGOXYSU-UHFFFAOYSA-N | | SMILES | Brc1cccnc1 | | LogP | 1.694 | | CAS DataBase Reference | 626-55-1(CAS DataBase Reference) | | NIST Chemistry Reference | Pyridine, 3-bromo-(626-55-1) | | EPA Substance Registry System | 3-Bromopyridine (626-55-1) |
| Hazard Codes | Xn,T,F,Xi | | Risk Statements | 10-22-36/37/38-23/24/25-20/21/22 | | Safety Statements | 26-45-38-36/37/39-28A-16 | | RIDADR | UN 1993 3/PG 3 | | WGK Germany | 3 | | F | 8 | | Hazard Note | Toxic/Flammable/Irritant | | TSCA | TSCA listed | | HazardClass | 6.1 | | PackingGroup | III | | HS Code | 29333999 | | Storage Class | 3 - Flammable liquids | | Hazard Classifications | Acute Tox. 4 Oral
Eye Irrit. 2
Flam. Liq. 3
Skin Irrit. 2
STOT SE 3 |
| | 3-Pyridyl bromide Usage And Synthesis |
| Chemical Properties | CLEAR COLOURLESS TO YELLOW LIQUID | | Uses | Pyridine as novel substrate for regioselective oxygenation with aromatic peroxygenase from Agrocybe aegerita. | | Uses | 3-Bromopyridine undergoes lithiation with LDA at low temperatures in the 4-position: Heterocycles, involved in formation of the Grignard by Mg exchange with i-PrMgCl and in transmetallation of the lithiated derivative with zinc chloride followed by treatment with an electrophile as a route to 4-substituted 3-bromopyridines. | | Definition | ChEBI: A monobromopyridine in which the bromo substituent is located at position 3. | | Synthesis Reference(s) | Synthesis, p. 293, 1974 DOI: 10.1055/s-1974-23300 | | Synthesis | A method for synthesizing 3-bromopyridine, comprising the steps of:
Add 60 g of pyridine and 100 mL of water to a 500 mL three-necked flask, add 40% HBr (160 g, temperature control of 20-30 during the process of addition) dropwise with stirring, stirring after the dropwise addition until dissolved clear, to obtain the brominated reaction solution;
Heat the bromination reaction solution to 70 and slowly add 30% H2O280mL, drop process control temperature 70-80 (drop process slowly exothermic), drop after the completion of the temperature control 80 stirring reaction for 24 hours, to get the crude products; _x000D
The crude product was cooled down to below 10, the pH was adjusted to pH=8 with 3N NaOH aqueous solution, ethyl acetate (350mL×3) was added to extract, and the organic phase was backwashed with aqueous sodium sulfite to obtain the extract (organic phase);
The extract (organic phase) was concentrated and then distilled under reduced pressure, that is, 31 g of 3-bromopyridine was obtained, and the GC purity was 85.1%.
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| | 3-Pyridyl bromide Preparation Products And Raw materials |
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