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| | 2-Amino-3-[(4-methoxybenzyl)thio]propanoic acid Basic information |
| | 2-Amino-3-[(4-methoxybenzyl)thio]propanoic acid Chemical Properties |
| Melting point | 198-199 °C(Solv: water (7732-18-5)) | | Boiling point | 417.6±45.0 °C(Predicted) | | density | 1.257±0.06 g/cm3(Predicted) | | storage temp. | Keep in dark place,Inert atmosphere,2-8°C | | solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | | pka | 2.08±0.10(Predicted) | | form | Solid | | color | White to off-white | | CAS DataBase Reference | 2544-31-2(CAS DataBase Reference) |
| | 2-Amino-3-[(4-methoxybenzyl)thio]propanoic acid Usage And Synthesis |
| Chemical Properties | White to off-white powder | | Uses | H-Cys(pMeOBzl)-OH is a cysteine derivative[1]. | | Synthesis | (Step 1) Add 1-(chloromethyl)-4-methoxybenzene (280 g, 1780 mmol) dissolved in ether (400 mL) and concentrated hydrochloric acid to a mixture of ether (400 mL) and concentrated hydrochloric acid dropwise for 2 hours. After the dropwise addition was completed, the mixture was continued to be stirred for 1 hour. The organic layer was separated and added to a solution prepared from L-cysteine (197 g, 1625 mmol) and 2N aqueous sodium hydroxide (980 mL) dissolved in ethanol (1890 mL). The mixture was stirred at room temperature for 2 hours. Upon completion of the reaction, the mixture was cooled to 0 °C and neutralized with aqueous 3N hydrochloric acid to pH 7. The resulting solid was collected by filtration and dried to afford S-(4-methoxybenzyl)-L-cysteine (250 g, 1035 mmol, 64% yield). | | References | [1] Luckose F, et al. Effects of amino acid derivatives on physical, mental, and physiological activities. Crit Rev Food Sci Nutr. 2015;55(13):1793-807. DOI:10.1080/10408398.2012.708368 |
| | 2-Amino-3-[(4-methoxybenzyl)thio]propanoic acid Preparation Products And Raw materials |
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