- Polyphyllin VI
-
- $110.00
-
2026-06-02
- CAS:55916-51-3
- Purity: 99.72%
- Supply Ability: 10g
- Polyphyllin VI
-
- $2.00
-
2019-07-06
- CAS:55916-51-3
- Min. Order: 1KG
- Purity: 98%
- Supply Ability: 10000kg
|
| | Polyphyllin VI Basic information |
| Product Name: | Polyphyllin VI | | Synonyms: | Polyhyllin VI;(2R,3R,4R,5R,6S)-2-(((2R,3R,4S,5S,6R)-4,5-Dihydroxy-2-(((2'R,4S,5'R,6aR,6bS,8aS,8bS,9S,11aS,12;Polyphyllin VI;Polyphyllin F (Polyphyllin VI);17-Hydroxyparis V;Paris saponin VI;Paris VI;product/154909 | | CAS: | 55916-51-3 | | MF: | C39H62O13 | | MW: | 738.9 | | EINECS: | | | Product Categories: | chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract | | Mol File: | 55916-51-3.mol |  |
| | Polyphyllin VI Chemical Properties |
| Melting point | 216-220°C | | Boiling point | 871.2±65.0 °C(Predicted) | | density | 1.38 | | storage temp. | Hygroscopic, Refrigerator, under inert atmosphere | | solubility | DMSO (Slightly), Methanol (Slightly) | | form | Solid | | pka | 12.85±0.70(Predicted) | | color | White to Off-White | | InChIKey | WHWWQGPCTUQCMN-PICXMRMANA-N |
| | Polyphyllin VI Usage And Synthesis |
| Chemical Properties | White crystalline powder, easily soluble in methanol and water, derived from Paris polyphylla. | | Uses | Polyhyllin VI is a natural saponin extracted from the plant, Rhizoma Paridis, and displays anti-proliferative activity in vivo. Used in the treatment of HepG2 cells for tumor mitigation. | | in vivo | Polyphyllin VI (2-4 mg/kg; i.p.; five times a week for 4 weeks) inhibits the growth of lung cancer tumor xenografts[1].
Polyphyllin VI (2.5-10 mg/kg; i.p.; 10 consecutive days) activates NLRP3 inflammasome in A549-bearing athymic nude mice[3].
| Animal Model: | A549 tumor xenografts subcutaneously inoculated into the right flank of the nude mice[1] | | Dosage: | 2 mg/kg, 3 mg/kg, 4 mg/kg | | Administration: | Intraperitoneal Injection (i.p.) | | Result: | Resulted the reduction of tumor volume to 25.63%, 41.71%, and 40.41%, respectively, after 2 mg/kg, 3 mg/kg and 4 mg/kg treatment. |
| Animal Model: | A549 tumor xenografts subcutaneously inoculated into the right flank of the nude mice[3] | | Dosage: | 2.5 mg/kg, 5 mg/kg, 10 mg/kg | | Administration: | Intraperitoneal Injection (i.p.) | | Result: | Showed the expression of NLRP3, caspase-1, IL-1β and GSDMD was increasing in a dose manner. |
|
| | Polyphyllin VI Preparation Products And Raw materials |
|