- PD153035
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- $35.00 / 10mg
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2026-01-26
- CAS:153436-54-5
- Min. Order:
- Purity: 98.92%
- Supply Ability: 10g
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| | PD 153035 HYDROCHLORIDE Basic information |
| Product Name: | PD 153035 HYDROCHLORIDE | | Synonyms: | 4-[(3-BROMOPHENYL)AMINO]-6,7-DIMETHOXYQUINAZOLINE HYDROCHLORIDE;PD 153035 HYDROCHLORIDE;PD153035HCl;PD153035;AG1517;PD-153035;AG-1517;ZM 252868;TYRPHOSTIN AG 1517;SU 5271;4-(3-Bromphenylamino)-6,7-bis(methoxy)quinazoline;4-(3-Bromphenylamino)-6,7-dimethylquinazoline;4-Quinazolinamine, N-(3-bromphenyl)-6,7-dimethoxy-;Zinc00600292 | | CAS: | 153436-54-5 | | MF: | C16H14BrN3O2 | | MW: | 360.21 | | EINECS: | | | Product Categories: | Inhibitors;Inhibitor | | Mol File: | 153436-54-5.mol |  |
| | PD 153035 HYDROCHLORIDE Chemical Properties |
| Melting point | 189-190 °C | | Boiling point | 472.1±45.0 °C(Predicted) | | density | 1.499±0.06 g/cm3(Predicted) | | storage temp. | Keep in dark place,Inert atmosphere,2-8°C | | solubility | Soluble in DMSO (up to 5 mg/ml). | | form | White to off-white solid. | | pka | 5.55±0.30(Predicted) | | color | White or off-white | | Stability: | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months. | | InChI | 1S/C16H14BrN3O2/c1-21-14-7-12-13(8-15(14)22-2)18-9-19-16(12)20-11-5-3-4-10(17)6-11/h3-9H,1-2H3,(H,18,19,20) | | InChIKey | LSPANGZZENHZNJ-UHFFFAOYSA-N | | SMILES | Brc1cc(ccc1)Nc2ncnc3c2cc(c(c3)OC)OC |
| WGK Germany | WGK 1 | | Storage Class | 11 - Combustible Solids |
| | PD 153035 HYDROCHLORIDE Usage And Synthesis |
| Description | AG-1517 HCl (153436-54-5) is an ultra-potent inhibitor of epidermal growth factor receptor tyrosine kinase (EGFR), with an IC50 of 25 pM. Inhibits other tyrosine kinases at micromolar or higher concentrations. It selectively blocks EGF-mediated cellular processes including mitogenesis, early gene expression and oncogenic transformation.1Inhibits the growth of a number of cancer cell lines.2AG-1517 HCl is an extremely useful tool for exploring EGF-mediated cellular signaling.3 | | Chemical Properties | Yellowish solid | | Uses | PD153035 is an inhibitor of EGFR, competitive with ATP. EGF Receptor: IC50 = 25 pM (Ki = 6 pM). | | Uses | PD 153035 is an extremely potent and specific inhibitor of EGFR tyrosine kinase activity. | | Definition | ChEBI: A member of the class of quinazolines carrying a 3-bromophenylamino substituent at position 4 and two methoxy substituents at positions 6 and 7. | | Biological Activity | An extremely potent inhibitor of epidermal growth factor (EGF) receptor tyrosine kinase, with an IC 50 of 25 pM. Inhibits other purified tyrosine kinases only at micromolar or higher concentrations. | | Synthesis | GENERAL METHOD: 4-Chloro-6,7-dimethoxyquinazoline (1 mmol) was dissolved in refluxing 2-propanol (20 mL) and m-bromoaniline (1 mmol) was added dropwise. The reaction mixture was refluxed for 3-4 hours and the progress of the reaction was monitored by TLC until completion. Upon completion of the reaction, the precipitate was filtered out and washed sequentially with 2-propanol (10 mL) and ether (10 mL). If no precipitate formation was observed, the solvent was removed under reduced pressure to obtain a solid product. The final product was purified by recrystallization from 75% ethanol solution. | | target | EGFR | | References | [1] DAVID W. FRY. A Specific Inhibitor of the Epidermal Growth Factor Receptor Tyrosine Kinase[J]. Science, 1994, 265 5175. DOI:10.1126/science.8066447
[2] M BOS. PD153035, a tyrosine kinase inhibitor, prevents epidermal growth factor receptor activation and inhibits growth of cancer cells in a receptor number-dependent manner.[J]. Clinical Cancer Research, 1997, 3 11: 2099-2106.
[3] MARIE-PIER TÉTREAULT. Specific signaling cascades involved in cell spreading during healing of micro-wounded gastric epithelial monolayers[J]. Journal of cellular biochemistry, 2008, 105 5: 1240-1249. DOI:10.1002/jcb.21924 |
| | PD 153035 HYDROCHLORIDE Preparation Products And Raw materials |
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