| Company Name: |
ChemPep, Inc. |
| Tel: |
+1 (888) 615-9178 / (561) 791-8787 |
| Email: |
service@chempep.com |
| Company Name: |
T&W GROUP |
| Tel: |
021-61551611 13296011611 |
| Email: |
contact@trustwe.com |
|
| | HS-PEG4-tBu Basic information |
| Product Name: | HS-PEG4-tBu | | Synonyms: | HS-PEG4-tBu;HS-PEG4-COOtBu;15-Mercapto-4,7,10,13-tetraoxapentadecanoic acid tert-butyl ester;SH-PEG4-CH2CH2COOtBu;15-Mercapto-4,7,10,13-tetraoxapentadecanoic acid 1,1-dimethylethyl ester;HS-PEG4-CH2CH2COOtBu;HS-PEG4-CH2CH2COOtBu;Thio-PEG4-t-butyl ester | | CAS: | 564476-33-1 | | MF: | C15H30O6S | | MW: | 338.46 | | EINECS: | | | Product Categories: | peg | | Mol File: | 564476-33-1.mol |  |
| | HS-PEG4-tBu Chemical Properties |
| Boiling point | 414.6±40.0 °C(Predicted) | | density | 1.060±0.06 g/cm3(Predicted) | | storage temp. | 2-8°C, stored under nitrogen | | pka | 9+-.0.10(Predicted) | | form | Liquid | | color | Colorless to light yellow |
| | HS-PEG4-tBu Usage And Synthesis |
| Description | Thiol-PEG4-t-butyl ester is a PEG linker containing a thiol group and a t-butyl ester. The hydrophilic PEG spacer increases solubility in aqueous media. The thiol group reacts with maleimide, OPSS, vinylsulfone and transition metal surfaces including gold, silver, etc. The t-butyl protected carboxyl group can be deprotected under acidic conditions. | | Uses | Thiol-PEG4-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | | IC 50 | PEGs; Alkyl/ether | | References | [1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
| | HS-PEG4-tBu Preparation Products And Raw materials |
|