1-Isopropylpyrazole-5-boronic Acid manufacturers
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| | 1-Isopropylpyrazole-5-boronic Acid Basic information | | Application |
| Product Name: | 1-Isopropylpyrazole-5-boronic Acid | | Synonyms: | 1-Isopropylpyrazole-5-boronic Acid;1-isopropyl-1H-pyrazol-5-ylboronic acid;1-Isopropyl-1H-pyrazole-5-boronic acid;Boronic acid, [1-(1-methylethyl)-1H-pyrazol-5-yl]-;1-Isopropyl-1H-pyrazole-5-boronic acid 95+%;(2-propan-2-ylpyrazol-3-yl)boronic acid;B-[1-(1-methylethyl)-1H-pyrazol-5-yl]-Boronic acid;Boronic acid, B-[1-(1-methylethyl)-1H-pyrazol-5-yl]- | | CAS: | 839714-33-9 | | MF: | C6H11BN2O2 | | MW: | 153.97 | | EINECS: | | | Product Categories: | | | Mol File: | 839714-33-9.mol |  |
| | 1-Isopropylpyrazole-5-boronic Acid Chemical Properties |
| Boiling point | 312.0±34.0 °C(Predicted) | | density | 1.15±0.1 g/cm3(Predicted) | | storage temp. | Inert atmosphere,Store in freezer, under -20°C | | pka | 8.02±0.58(Predicted) | | form | solid | | Appearance | White to off-white Solid |
| | 1-Isopropylpyrazole-5-boronic Acid Usage And Synthesis |
| Application | 1-Isopropylpyrazole-5-boronic acid can be used as an organic synthesis intermediate and a pharmaceutical intermediate in laboratory research and development processes and in the synthesis of pharmaceutical chemicals. | | Synthesis | The general procedure for the synthesis of 1-isopropylpyrazole-5-boronic acid from 1-isopropylpyrazole was as follows: n-BuLi (17.46 g, 110 ml, 273 mM in hexane) was slowly added to a THF solution of 1-isopropyl-1H-pyrazole over a period of 30 min at -78 °C. The reaction mixture was stirred at -78 °C for 2 hours. Subsequently, a cooled solution of triisopropoxyborate (170.0 g, 909 mmol) was slowly added through a cannula over 45 minutes. The reaction mixture was slowly warmed from -50 °C to room temperature and stirred overnight. The pH of the reaction mixture was adjusted to 6-7 with 1 M HCl (170 mL). the solvent was evaporated to dryness and the resulting residue was ground with a 1:1 mixture of ethyl acetate:dichloromethane. The suspension was filtered and the solvent was evaporated in vacuo to give 1-isopropylpyrazole-5-boronic acid as a colorless solid (20.0 g, 58% yield).LCMS m/z (%) = 154 [M+H]+ (100).1H NMR (400 MHz, DMSO-d6) δ: 8.14 (s, 2H), 7.2 (s, 1H), 6.5 (s, 1H). 5.05 (m, 1H), 1.2 (d, J = 9.0Hz, 6H). | | References | [1] Journal of Medicinal Chemistry, 2010, vol. 53, # 5, p. 1923 - 1936
[2] Patent: WO2005/12254, 2005, A1. Location in patent: Page/Page column 129 |
| | 1-Isopropylpyrazole-5-boronic Acid Preparation Products And Raw materials |
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