UNC-926
| 中文名称 | UNC-926 |
|---|---|
| 中文同义词 | 化合物UNC 926 HYDROCHLORIDE;化合物UNC 926;(3-溴苯基)(4-(吡咯烷基-1-基)哌啶-1-基)酮;化合物UNC 926,10 MM DMSO 溶液;UNC-926 ,S5262;UNC-926 试剂;1184136-10-4;UNC-926;UNC-926 试剂 |
| 英文名称 | UNC-926 Hydochloride |
| 英文同义词 | UNC-926 Hydochloride;UNC-926;(3-Bromophenyl)[4-(1-prrolidinyl)-1-piperidinyl]methanone hydrochloride;UNC926;UNC-926;UNC 926;UNC-926 Hydrochloride;(3-Bromophenyl)[4-(1-pyrrolidinyl)-1-piperidinyl]-methanone;(3-bromophenyl)-(4-pyrrolidin-1-ylpiperidin-1-yl)methanone;Methanone, (3-bromophenyl)[4-(1-pyrrolidinyl)-1-piperidinyl]- |
| CAS号 | 1184136-10-4 |
| 分子式 | C16H21BrN2O |
| 分子量 | 337.25 |
| EINECS号 | |
| 相关类别 | Amines;Aromatics;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals |
| Mol文件 | 1184136-10-4.mol |
| 结构式 |  |
UNC-926 性质
| 储存条件 | 2-8°C |
|---|---|
| 溶解度 | DMSO：可溶，2mg/mL，澄清（加热） |
| 形态 | 粉末 |
| 颜色 | 白色至浅棕色 |
| InChI | InChI=1S/C16H21BrN2O/c17-14-5-3-4-13(12-14)16(20)19-10-6-15(7-11-19)18-8-1-2-9-18/h3-5,12,15H,1-2,6-11H2 |
| InChIKey | OWGLFIKZKQOYHZ-UHFFFAOYSA-N |
| SMILES | C(C1=CC=CC(Br)=C1)(N1CCC(N2CCCC2)CC1)=O |
UNC926 是一种 methyl-lysine (Kme) reader domain 抑制剂，可特异性抑制 L3MBTL1，其 IC50 为 3.9 μM。
| Target | Value |
|
L3MBTL1
() | 3.9 μM(Kd) |
UNC926 also exhibits a low micromolar affinity for the close homolog, L3MBTL3 ( IC
50
of 3.2 μM), with a decrease in affinity for the other MBT domains and no binding to CBX7.
UNC926 (1-25 μM) inhibits binding of the 3xMBT domain to H4K20me1.UNC926 inhibits the association of L3MBTL13xMBT with the appropriate histonepeptides in a dose-dependent manner. UNC926 does not have an effect on the binding of 53BP1 to H4K20me1, demonstrating specificity of UNC926 for L3MBTL1 over 53BP1.
用途
UNC-926 is a methyl-lysine reader antagonist; binds to the MBT domain of the L3MBTL1 protein (Kd = 3.9 μM). UNC-926 selectively inhibits the interaction between L3MBTL13XMBT-H4K20me1 in a peptide pull down assay.
安全信息
| WGK Germany | 3 |
|---|
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2026/09/15 | HY-16510 | UNC926 | 1184136-10-4 | 1 mg | 166元 |
| 2026/09/15 | HY-16510 | UNC-926 UNC926 | 1184136-10-4 | 5mg | 415元 |