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Energy Chemical |
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- 6-Methoxy-3-pyridinol
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- $1.10
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2026-08-25
- CAS:51834-97-0
- Min. Order: 1KG
- Purity: 99%min
- Supply Ability: 100KG
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| | 5-Hydroxy-2-methoxypyridine Basic information |
| | 5-Hydroxy-2-methoxypyridine Chemical Properties |
| Melting point | 81 °C | | Boiling point | 330.1±22.0 °C(Predicted) | | density | 1.190±0.06 g/cm3(Predicted) | | storage temp. | Inert atmosphere,Room Temperature | | form | crystalline powder | | pka | 9.69±0.10(Predicted) | | color | Lemony beige | | InChI | InChI=1S/C6H7NO2/c1-9-6-3-2-5(8)4-7-6/h2-4,8H,1H3 | | InChIKey | LKBKDKVMHWPZDB-UHFFFAOYSA-N | | SMILES | C1=NC(OC)=CC=C1O |
| HazardClass | IRRITANT | | HS Code | 2933399990 |
| | 5-Hydroxy-2-methoxypyridine Usage And Synthesis |
| Uses | 5-Hydroxy-2-methoxypyridine, is a heterocyclic building block used in various chemical synthesis. | | Synthesis | Step 2. Synthesis of 5-hydroxy-2-methoxypyridine: To a stirred solution of 5-bromo-2-methoxypyridine (8.9 g, 47.9 mmol) in tetrahydrofuran (THF, 175 mL) was added slowly and dropwise to a solution of n-butyllithium (2.5 M hexane solution, 28.7 mL, 71.8 mmol) at -78 °C. The reaction was continued for 45 min with stirring. The reaction mixture was stirred continuously at -78 °C for 45 min. Subsequently, trimethyl borate (7.06 mL, 62.2 mmol) was added via syringe and the mixture continued to be stirred at the same temperature for 2 hours. The reaction mixture was warmed up to 0 °C and treated by adding a mixture of 3N NaOH solution (25 mL, 71.77 mmol) and 30% hydrogen peroxide solution (~50 mL). The reaction mixture gradually turned yellow and slightly turbid and was then warmed to room temperature, held for 30 minutes and then heated to reflux temperature and maintained for 1 hour. After completion of the reaction, the mixture was cooled to room temperature. The aqueous layer was neutralized with 1N HCl solution and subsequently extracted with ether (Et2O, 2 x 100 mL). The organic layers were combined, dried with anhydrous sodium sulfate (Na2SO4) and concentrated under reduced pressure to give a yellow viscous oily product (3.5 g, 60% yield). | | References | [1] Medicinal Chemistry Research, 2013, vol. 22, # 4, p. 1825 - 1836
[2] Heterocycles, 2002, vol. 57, # 1, p. 55 - 71
[3] Patent: EP1449834, 2004, A2. Location in patent: Page 27
[4] Patent: EP1042305, 2005, B1. Location in patent: Page/Page column 33
[5] Patent: US2003/207914, 2003, A1. Location in patent: Page/Page column 12 |
| | 5-Hydroxy-2-methoxypyridine Preparation Products And Raw materials |
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