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| | 1,4-Amino-N,N-dimethylaniline,dihydrochloride Basic information |
| Product Name: | 1,4-Amino-N,N-dimethylaniline,dihydrochloride | | Synonyms: | 1,4-Amino-N,N-dimethylaniline,dihydrochloride;1,4-Benzenediamine,N,N-dimethyl-,dihydrochloride;4-benzenediamine,n,n-dimethyl-dihydrochloride;dimethyl-p-phenylenediaminehydrochloride;N,N-Dimethyl-p-phenylenediami;n,n-dimethyl-p-phenylenediamindihydrochloride;N,N-DIMETHYL-P-PHENYLENEDIAMINE HYDROCHLORIDE;N,N-DIMETHYL-P-PHENYLENEDIAMMONIUM DICHLORIDE | | CAS: | 536-46-9 | | MF: | C8H13ClN2 | | MW: | 172.66 | | EINECS: | 208-635-7 | | Product Categories: | API intermediates;Intermediates of Dyes and Pigments | | Mol File: | 536-46-9.mol |  |
| | 1,4-Amino-N,N-dimethylaniline,dihydrochloride Chemical Properties |
| Melting point | 222 °C (dec.)(lit.) | | bulk density | 500kg/m3 | | storage temp. | Keep in dark place,Inert atmosphere,Room temperature | | solubility | 2000g/l | | form | Powder | | color | White to beige to gray | | PH | 1.6 (50g/l, H2O, 20℃) | | Water Solubility | Soluble in water | | Merck | 14,3254 | | BRN | 3913463 | | Major Application | food and beverages || microbiology | | InChI | InChI=1S/C8H12N2.2ClH/c1-10(2)8-5-3-7(9)4-6-8;;/h3-6H,9H2,1-2H3;2*1H | | InChIKey | IAEDWDXMFDKWFU-UHFFFAOYSA-N | | SMILES | N(C1C=CC(N)=CC=1)(C)C.Cl.Cl | | CAS DataBase Reference | 536-46-9(CAS DataBase Reference) | | EPA Substance Registry System | 1,4-Benzenediamine, N,N-dimethyl-, dihydrochloride (536-46-9) |
| Hazard Codes | T | | Risk Statements | 23/24/25-43 | | Safety Statements | 36/37-45 | | RIDADR | UN 2811 6.1/PG 2 | | WGK Germany | 3 | | RTECS | ST1750000 | | F | 3-8-9 | | TSCA | TSCA listed | | HS Code | 2921 51 90 | | HazardClass | 6.1 | | PackingGroup | III | | Storage Class | 6.1A - Combustible acute toxic Cat. 1 and 2
very toxic hazardous materials | | Hazard Classifications | Acute Tox. 3 Dermal
Acute Tox. 3 Inhalation
Acute Tox. 3 Oral |
| | 1,4-Amino-N,N-dimethylaniline,dihydrochloride Usage And Synthesis |
| Chemical Properties | white to beige to grey powder | | Uses | It is a stain used in microscopy. N,N-Dimethyl-p-phenylenediamine dihydrochloride is also suitable for use in the peroxidase test. It is a compound that is normally used to measure the antioxidant potential. | | Biological Activity | N,N-Dimethyl-p-phenylenediamine dihydrochloride (DMPD) is used for the determination of peroxidase. DMPD is converted into a red pigment of semiquinone nature. It is also used in the HID-AB (high iron diamine-alcian blue) staining procedures, which are used to differentiate between sialomucin and sulfomucin in the gastrointestinal tract. | | Synthesis | A method for the preparation of 1,4-Amino-N,N-dimethylaniline,dihydrochloride, comprising the steps of:
(1) Take 1 mole of p-nitrochlorobenzene and dissolve it in 400 ml of toluene to obtain solution A;
(2) Take 1.1 mole of dimethylamine hydrochloride dissolved in 180 ml of water, add solution A;
(3) 2025, under stirring, add 1.1 mole of 15% sodium hydroxide aqueous solution to the above solution dropwise, warm up to 35, add 0.66 mole of 15% sodium hydroxide aqueous solution dropwise again in 30 minutes, and then keep warm and react for 60 minutes;
(4) Stilling, phase separation, toluene layer with active nickel catalyst, hydrogen reduction;
(5) Separation of the catalyst by filtration; the toluene layer is passed through hydrogen chloride gas to give a precipitate of N,N-dimethyl-p-phenylenediamine dihydrochloride;
(6) Centrifugation, obtained 1,4-Amino-N,N-dimethylaniline,dihydrochloride 198g, content 99.7%, yield 94.5% (as p-chloronitrobenzene).
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| | 1,4-Amino-N,N-dimethylaniline,dihydrochloride Preparation Products And Raw materials |
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