- Bis-propargyl-PEG5
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2025-06-07
- CAS:159428-42-9
- Min. Order: 5g
- Purity: >98.00%
- Supply Ability: 5g
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| | 4,7,10,13,16-Pentaoxanonadeca-1,18-diyne Basic information |
| Product Name: | 4,7,10,13,16-Pentaoxanonadeca-1,18-diyne | | Synonyms: | 4,7,10,13,16-Pentaoxanonadeca-1,18-diyne;Bis-propargyl-PEG5;Alkyne-PEG5-Alkyne;PROPARGYL-PEG5-PROPARGYL;Propyl ether-PEG3-Propyl ether;1,11-bis(2-propyn-1-oxy)-3,6,9-trioxaundecane;Tetraethylene glycol dipropargyl ether;Bis-propargyl-PEG4/4,7,10,13,16-Pentaoxanonadeca-1,18-diyne | | CAS: | 159428-42-9 | | MF: | C14H22O5 | | MW: | 270.32 | | EINECS: | | | Product Categories: | peg | | Mol File: | 159428-42-9.mol |  |
| | 4,7,10,13,16-Pentaoxanonadeca-1,18-diyne Chemical Properties |
| Boiling point | 338.7±37.0 °C(Predicted) | | density | 1.043±0.06 g/cm3(Predicted) | | storage temp. | Storage temp. 2-8°C | | form | Liquid | | color | Colorless to light yellow | | InChI | 1S/C14H22O5/c1-3-5-15-7-9-17-11-13-19-14-12-18-10-8-16-6-4-2/h1-2H,5-14H2 | | InChIKey | FCPHAZIYRMYSTF-UHFFFAOYSA-N | | SMILES | C#CCOCCOCCOCCOCCOCC#C |
| HS Code | 2909199090 | | Storage Class | 13 - Non Combustible Solids |
| | 4,7,10,13,16-Pentaoxanonadeca-1,18-diyne Usage And Synthesis |
| Description | Bis-propargyl-PEG5 is a crosslinker containing propargyl groups at both ends. The propargyl groups reacts with azide-bearing compounds or biomolecules via copper catalyzed Click Chemistry to form stable triazole linkages. | | Uses | Bis-propargyl-PEG4 is a PEG-based PROTAC linker used in the synthesis of PROTACs. Bis-propargyl-PEG4 is used for the synthesis of demethylvancomycin dimers[1][2]. Bis-propargyl-PEG4 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. | | References | [1] Pearlie BURNETTE, et al. Dimeric immuno-modulatory compounds against cereblon-based mechanisms. WO2020014489A2.
[2] Jiang, et al. Design, synthesis and biological activity of novel demethylvancomycin dimers against vancomycin-resistant enterococcus faecalis. Tetrahedron, 2018: 74(27), 3527–3533. |
| | 4,7,10,13,16-Pentaoxanonadeca-1,18-diyne Preparation Products And Raw materials |
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