- Lenvatinib Impurity
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- $0.00 / 10mg
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2025-12-16
- CAS:205448-64-2
- Min. Order: 10mg
- Purity: 95%+
- Supply Ability: 100000
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| | 4-[(2,2-Dimethyl-4,6-dioxo-[1,3]dioxan-5-ylidenemethyl)-amino]-2-methoxy-benzoic acid methyl ester Basic information |
| Product Name: | 4-[(2,2-Dimethyl-4,6-dioxo-[1,3]dioxan-5-ylidenemethyl)-amino]-2-methoxy-benzoic acid methyl ester | | Synonyms: | 4-[(2,2-Dimethyl-4,6-dioxo-[1,3]dioxan-5-ylidenemethyl)-amino]-2-methoxy-benzoic acid methyl ester;Methyl 4-(((2,2-dimethyl-4,6-dioxo-1,3-dioxan-5-ylidene)methyl)amino)-2-methoxybenzoate;methyl 4-((2,2-dimethyl-4,6-dioxo-1,3-dioxan-5-ylidene)methylamino);METHYL4-[(2,2-DIMETHYL-4,6;lenvaint-B;)amino)-2-methoxybenzoate;4-(((2,2-dimethyL;-4,6-dioxo-1,3-dioxan-5-yL | | CAS: | 205448-64-2 | | MF: | C16H17NO7 | | MW: | 335.31 | | EINECS: | | | Product Categories: | | | Mol File: | 205448-64-2.mol | ![4-[(2,2-Dimethyl-4,6-dioxo-[1,3]dioxan-5-ylidenemethyl)-amino]-2-methoxy-benzoic acid methyl ester Structure](CAS/20180703/GIF/205448-64-2.gif) |
| | 4-[(2,2-Dimethyl-4,6-dioxo-[1,3]dioxan-5-ylidenemethyl)-amino]-2-methoxy-benzoic acid methyl ester Chemical Properties |
| Boiling point | 547.8±50.0 °C(Predicted) | | density | 1.360±0.06 g/cm3(Predicted) | | storage temp. | 2-8°C(protect from light) | | pka | -3+-.0.40(Predicted) | | Appearance | Off-white to yellow Solid |
| | 4-[(2,2-Dimethyl-4,6-dioxo-[1,3]dioxan-5-ylidenemethyl)-amino]-2-methoxy-benzoic acid methyl ester Usage And Synthesis |
| Synthesis | The general procedure for the synthesis of methyl 4-((2,2-dimethyl-4,6-dioxo-1,3-dioxan-5-yl)methylamino)-2-methoxybenzoate from 5-(methoxymethylenyl)-2,2-dimethyl-1,3-dioxane-4,6-dione and 2-methoxy-4-aminobenzoic acid methyl ester was as follows: first, 2-methoxy-4-aminobenzoic acid methyl ester (14.15 g, 78 mmol) was suspended in isopropanol and heated at 50 °C. Subsequently, 5-(methoxymethylenyl)-2,2-dimethyl-1,3-dioxohexane-4,6-dione (14.8 g, 80 mmol) was added in batches over 10 min. The reaction mixture was heated to reflux for 30 minutes. After completion of the reaction, the mixture was cooled to room temperature and the precipitate formed was collected by filtration. The precipitate was washed with isopropanol and dried under vacuum to afford the target product 5-((3-methoxy-4-methoxycarbonylanilino)methylene)-2,2-dimethyl-1,3-dioxane-4,6-dione (25.2 g, 96% yield). | | References | [1] Patent: US6809097, 2004, B1. Location in patent: Page column 67
[2] Patent: EP1724268, 2006, A1. Location in patent: Page/Page column 48
[3] Journal of Medicinal Chemistry, 2008, vol. 51, # 6, p. 1649 - 1667
[4] Journal of Medicinal Chemistry, 2008, vol. 51, # 6, p. 1668 - 1680 |
| | 4-[(2,2-Dimethyl-4,6-dioxo-[1,3]dioxan-5-ylidenemethyl)-amino]-2-methoxy-benzoic acid methyl ester Preparation Products And Raw materials |
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