| Company Name: |
SYNTHENTA PVT LTD
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| Tel: |
+91-7416102217 +91-7416102217 |
| Email: |
gvpratapreddy@synthenta.com |
| Products Intro: |
Product Name:Nifedipine D6
CAS:1188266-14-9
Purity:97-99% Package:1kg,5kg, 10kg, 25kg & 50kg
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| Company Name: |
J & K SCIENTIFIC LTD.
|
| Tel: |
18210857532; 18210857532 |
| Email: |
jkinfo@jkchemical.com |
| Products Intro: |
Product Name:Nifedipine-d6
CAS:1188266-14-9
Package:10Mg,1Mg
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- Nifedipine-D6
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- $259.00
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2026-05-11
- CAS:1188266-14-9
- Purity:
- Supply Ability: 10g
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| | NIFEDIPINE-D6 Basic information |
| | NIFEDIPINE-D6 Chemical Properties |
| Melting point | 164-165°C | | storage temp. | -20°C Freezer | | solubility | Chloroform (Slightly), Methanol (Slightly, Heated) | | form | Solid | | color | Yellow |
| | NIFEDIPINE-D6 Usage And Synthesis |
| Description | Nifedipine-d6 is intended for use as an internal standard for the quantification of nifedipine by GC- or LC-MS. Nifedipine is a dihydropyridine L-type calcium channel blocker that reduces the amplitude of spontaneous contractions in isolated rabbit ileum when used at a concentration of 1 μM. Nifedipine (1 μM) reduces TGF-β-induced calcium oscillations in human fibroblasts and prevents impairment of lung function in a mouse model of pulmonary fibrosis induced by bleomycin when administered at a dose of 10 mg/kg per day. It also reduces increases in mean arterial blood pressure induced by angiotensin II in spontaneously hypertensive rats when administered at a dose of 10 μg/kg. Formulations containing nifedipine have been used in the treatment of hypertension and angina. | | Chemical Properties | Yellow Solid | | Uses | (Nifedipine-d6) Labeled Nifedipine, intended for use as an internal standard for the quantification of Nifedipine by GC- or LC-mass spectrometry. | | Uses | Used as an antihypertensive and antianginal. A labelled dihydorpyridine calcium channel blocker. | | References | [1] MERHAN RAGY Eman E. The role of nitric oxide and L-type calcium channel blocker in the contractility of rabbit ileum in vitro.[J]. Journal of physiology and biochemistry, 2012: 521-528. DOI: 10.1007/s13105-012-0167-x
[2] SUBHENDU MUKHERJEE. Disruption of Calcium Signaling in Fibroblasts and Attenuation of Bleomycin-Induced Fibrosis by Nifedipine.[J]. American Journal of Respiratory Cell and Molecular Biology, 2015, 53 4: 450-458. DOI: 10.1165/rcmb.2015-0009oc
[3] SHIZUKA ARITOMI Michihiro Y Tomoyuki Konda. L/N-type calcium channel blocker suppresses reflex aldosterone production induced by antihypertensive action.[J]. Heart and Vessels, 2012, 27 4: 419-423. DOI: 10.1007/s00380-011-0191-8 |
| | NIFEDIPINE-D6 Preparation Products And Raw materials |
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