| Company Name: |
Ajitha Prodrug India Pvt Ltd
|
| Tel: |
+91-9845915533 |
| Email: |
kavitha.sj@ajithaprodrug.com |
| Products Intro: |
Product Name:Tubulysin B
CAS:205304-87-6
Purity:99% Package:5 mg, 10 mg, 50 mg, 100 mg and 3 g
|
|
| | Tubulysin B Basic information |
| Product Name: | Tubulysin B | | Synonyms: | Tubulysin B;Benzenepentanoic acid, γ-[[[2-[(1R,3R)-1-(acetyloxy)-4-methyl-3-[[(2S,3S)-3-methyl-2-[[[(2R)-1-methyl-2-piperidinyl]carbonyl]amino]-1-oxopentyl][(1-oxobutoxy)methyl]amino]pentyl]-4-thiazolyl]carbonyl]amino]-4-hydroxy-α-methyl-, (αS,γR)-;(2S,4R)-4-({2-[(1R,3R)-1-(acetyloxy)-3-[(2S,3S)-N-[(butanoyloxy)methyl]-3-methyl-2-{[(2R)-1-methylpiperidin-2-yl]formamido}pentanamido]-4-methylpentyl]-1,3-thiazol-4-yl}formamido)-5-(4-hydroxyphenyl)-2-methylpentanoic acid | | CAS: | 205304-87-6 | | MF: | C42H63N5O10S | | MW: | 830.05 | | EINECS: | | | Product Categories: | | | Mol File: | 205304-87-6.mol |  |
| | Tubulysin B Chemical Properties |
| Boiling point | 978.0±65.0 °C(Predicted) | | density | 1.204±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | Soluble in DMSO | | form | Solid | | pka | 4.52±0.23(Predicted) | | color | White to off-white | | InChIKey | HWCIETDQUHYHGQ-OSGLCLOFNA-N |
| | Tubulysin B Usage And Synthesis |
| Description |
Tubulysin B is a highly cytotoxic peptide and potent microtubule destabilizing agent isolated from the myxobacteria Archangium geophyra and Angiococcus disciformis. Tubulysin B has IC50 values in the picomolar range against many cancer cell lines, including those with multidrug-resistant properties. It is a cytotoxic activity tubulysin which inhibits tubulin polymerization and leads to cell cycle arrest and apoptosis.
| | Uses | Tubulysin B is a highly cytotoxic peptide and potent microtubule destabilizing agents isolated from the myxobacteria Archangium geophyra and Angiococcus disciformis. Tubulysin B has IC50 values in the picomolar range against many cancer cell lines, including those with multidrug resistant properties[1].Tubulysin B is a cytotoxic activity tubulysin which inhibits tubulin polymerization and leads to cell cycle arrest and apoptosis[2]. | | Definition | ChEBI: Tubulysin B is a butyrate ester. | | in vitro |
Tubulysin B has IC50s of 0.6 and 0.9 nM against KB and A549 tumors cell lines, respectively.
| | References | [1] Leamon CP, et al. Prostate-Specific Membrane Antigen-Specific Antitumor Activity of a Self-Immolative Tubulysin Conjugate. Bioconjug Chem. 2019 Jun 19;30(6):1805-1813. DOI:10.1021/acs.bioconjchem.9b00335
[2] Vlahov IR, et al. Acid mediated formation of an N-acyliminium ion from tubulysins: a new methodology for the synthesis of natural tubulysins and their analogs. Bioorg Med Chem Lett. 2011 Nov 15;21(22):6778-81. DOI:10.1016/j.bmcl.2011.09.041 |
| | Tubulysin B Preparation Products And Raw materials |
|