2,3-DIMETHYL-6-NITROANILINE manufacturers
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| | 2,3-DIMETHYL-6-NITROANILINE Basic information |
| Product Name: | 2,3-DIMETHYL-6-NITROANILINE | | Synonyms: | TIMTEC-BB SBB006536;6-NITRO-2,3-XYLIDINE;2,3-DIMETHYL-6-NITROANILINE;2,3-Dimethyl-6-nitroaniline,6-Nitro-2,3-xylidine;(2,3-Dimethyl-6-nitrophenyl)amine;6-Nitro-2,3-xylidine, 2-Amino-3,4-dimethylnitrobenzene, 3-Amino-4-nitro-o-xylene;2,3-DIMETHYL-6-NITROANILINE 98%;2,3-Dimethyl-6-nitroaniline,97% | | CAS: | 59146-96-2 | | MF: | C8H10N2O2 | | MW: | 166.18 | | EINECS: | | | Product Categories: | | | Mol File: | 59146-96-2.mol |  |
| | 2,3-DIMETHYL-6-NITROANILINE Chemical Properties |
| Melting point | 117-120 °C(lit.) | | Boiling point | 314.38°C (rough estimate) | | density | 1.220±0.06 g/cm3 (20 ºC 760 Torr) | | refractive index | 1.6273 (estimate) | | storage temp. | 2-8°C, protect from light | | form | Crystalline Powder | | pka | -0.16±0.25(Predicted) | | color | Dark yellow to orange-brown | | CAS DataBase Reference | 59146-96-2(CAS DataBase Reference) |
| Hazard Codes | Xn | | Risk Statements | 20/21/22-36/37/38 | | Safety Statements | 26-36 | | RIDADR | 2811 | | WGK Germany | 3 | | HazardClass | 6.1 | | PackingGroup | III | | HS Code | 29214200 |
| | 2,3-DIMETHYL-6-NITROANILINE Usage And Synthesis |
| Chemical Properties | dark yellow to orange-brown crystalline powder | | Uses | 2,3-Dimethyl-6-nitroaniline is an aromatic compound used in the study of C-H pi interactions and pi-pi stacking. | | Application | 2,3-Dimethyl-6-nitroaniline exhibits solubility in water, ethanol, and acetone, making it a versatile reagent for diverse scientific research applications.
| | Synthesis | General procedure for the synthesis of 2,3-dimethyl-6-nitroaniline and 2,3-dimethyl-4-nitroaniline from the compounds (CAS:114166-32-4) and N-(2,3-dimethyl-6-nitrophenyl)acetamide: To a solution of N-(2,3-dimethyl-6-nitrophenyl)acetamide (16.0 g, 1.0 equiv.) was added a 60% H2SO4 solution (150 mL). The reaction mixture was heated to reflux temperature, maintained for 1 hour and then cooled to room temperature. The solution was diluted with ice water (100 mL) and neutralized with 2N NaOH solution. The reaction mixture was extracted with EtOAc (3 x 50 mL). The organic phases were combined, washed sequentially with saturated NaHCO3 solution (2 × 50 mL) and saturated NaCl solution (2 × 50 mL), dried over anhydrous Na2SO4 and concentrated under reduced pressure. The residue was purified by column chromatography (10% CH2Cl2/hexane) to afford 2,3-dimethyl-6-nitroaniline (5.5 g, 43%) and 2,3-dimethyl-4-nitroaniline (1.5 g, 12%).
1H NMR data for 2,3-dimethyl-6-nitroaniline (5.5 g, 43%): δ 2.05 (s, 3H), 2.20 (s, 3H), 6.15 (br s, 2H), 6.45 (d, J=8.7 Hz, 1H), 7.63 (d, J=9.0 Hz, 1H) in CDCl3; δ 2.10 (s 3H), 2.30 (s, 3H), 6.50 (d, J=8.7Hz, 1H), 7.15 (br s, 2H), 7.75 (d, J=9.0Hz, 1H).
1H NMR data for 2,3-dimethyl-4-nitroaniline: δ 2.10 (s, 3H), 2.45 (s, 3H), 4.05 (br s, 2H), 6.45 (d, J=9.0 Hz, 1H), 7.65 (d, J=8.7 Hz, 1H) in CDCl3; δ 2.00 (s, 3H), 2.35 (s 3H), 6.12 (br s, 2H), 6.53 (d, J=9.0 Hz, 1H), 7.63 (d, J=9.0 Hz, 1H). | | References | [1] Patent: US6353006, 2002, B1. Location in patent: Page column 28-29 |
| | 2,3-DIMETHYL-6-NITROANILINE Preparation Products And Raw materials |
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