N-(4-((3-(trifluoromethyl)phenyl)sulfonyl)benzyl)-1H-pyrazolo[3,4-b]pyridine-5-carboxamide

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N-(4-((3-(trifluoromethyl)phenyl)sulfonyl)benzyl)-1H-pyrazolo[3,4-b]pyridine-5-carboxamide manufacturers

  • GNE-618
  • GNE-618 pictures
  • $178.00
  • 2026-05-11
  • CAS:1362151-42-5
  • Purity:
  • Supply Ability: 10g
N-(4-((3-(trifluoromethyl)phenyl)sulfonyl)benzyl)-1H-pyrazolo[3,4-b]pyridine-5-carboxamide Basic information
Product Name:N-(4-((3-(trifluoromethyl)phenyl)sulfonyl)benzyl)-1H-pyrazolo[3,4-b]pyridine-5-carboxamide
Synonyms:N-(4-((3-(trifluoromethyl)phenyl)sulfonyl)benzyl)-1H-pyrazolo[3,4-b]pyridine-5-carboxamide;1H-Pyrazolo[3,4-b]pyridine-5-carboxamide, N-[[4-[[3-(trifluoromethyl)phenyl]sulfonyl]phenyl]methyl]-;GNE-618;GNE618,GNE 618
CAS:1362151-42-5
MF:C21H15F3N4O3S
MW:460.4290096
EINECS:
Product Categories:
Mol File:1362151-42-5.mol
N-(4-((3-(trifluoromethyl)phenyl)sulfonyl)benzyl)-1H-pyrazolo[3,4-b]pyridine-5-carboxamide Structure
N-(4-((3-(trifluoromethyl)phenyl)sulfonyl)benzyl)-1H-pyrazolo[3,4-b]pyridine-5-carboxamide Chemical Properties
Boiling point 740.6±60.0 °C(Predicted)
density 1.479±0.06 g/cm3(Predicted)
solubility DMSO: Soluble
form Solid
pka8.97±0.40(Predicted)
color Off-white to light yellow
Safety Information
MSDS Information
N-(4-((3-(trifluoromethyl)phenyl)sulfonyl)benzyl)-1H-pyrazolo[3,4-b]pyridine-5-carboxamide Usage And Synthesis
DescriptionGNE-618 is an inhibitor of nicotinamide phosphoribosyl transferase (NAMPT).
UsesGNE-618 is a potent, orally active nicotinamide phosphoribosyl transferase (NAMPT) inhibitor with an IC50 of 6 nM. GNE-618 depletes NAD levels and induces tumor cell death. Anti-tumor activity[1].
in vivo

GNE-618 (100 mg/kg; p.o.; twice daily for 5 days) significantly inhibits tumor growth by 88% and has minimal effects on body weight in STO#81 patient-derived gastric model[1].

References[1] Xiao Y, et al. Dependence of tumor cell lines and patient-derived tumors on the NAD salvage pathway rendersthem sensitive to NAMPT inhibition with GNE-618. Neoplasia. 2013 Oct;15(10):1151-60. DOI:10.1593/neo.131304
[2] XIAOZHANG ZHENG . Identification of amides derived from 1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT)[J]. Bioorganic & Medicinal Chemistry Letters, 2013, 23 20: Pages 5488-5497. DOI: 10.1016/j.bmcl.2013.08.074
N-(4-((3-(trifluoromethyl)phenyl)sulfonyl)benzyl)-1H-pyrazolo[3,4-b]pyridine-5-carboxamide Preparation Products And Raw materials
Raw materials(4-((3-(trifluoromethyl)phenyl)sulfonyl)phenyl)methanamine-->1H-Pyrazolo[3,4-b]pyridine-5-carboxylic acid-->3-(Trifluoromethyl)phenylboronic acid
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