- L-Menthol
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2026-04-20
- CAS:2216-51-5
- Min. Order:
- Purity: 0.99
- Supply Ability:
- L-Menthol
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- $500.00/ kg
-
2026-04-20
- CAS:2216-51-5
- Min. Order: 1kg
- Purity: 99%
- Supply Ability: 5000
- L-Menthol
-
- $0.00 / 25KG
-
2026-04-20
- CAS:2216-51-5
- Min. Order: 1KG
- Purity: ≥99%
- Supply Ability: 500mt/year
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| | L-Menthol Basic information |
| | L-Menthol Chemical Properties |
| Melting point | 41-45 °C (lit.) | | alpha | -51 º (589nm, c=10, EtOH) | | Boiling point | 212 °C (lit.) | | bulk density | 450kg/m3 | | density | 0.89 g/mL at 25 °C (lit.) | | vapor pressure | 0.8 mm Hg ( 20 °C) | | refractive index | 1.46 | | FEMA | 2665 | MENTHOL RACEMIC | | Fp | 200 °F | | storage temp. | Store below +30°C. | | solubility | 490mg/l | | pka | 15.30±0.60(Predicted) | | form | Crystals or Crystalline Needles | | color | Colorless to white | | Specific Gravity | 0.89 | | Odor | at 10.00 % in dipropylene glycol. peppermint cooling mentholic minty | | Odor Type | mentholic | | Optical Rotation | [α]22/D 49°, c = 10 in 95% ethanol | | biological source | synthetic (organic) | | Water Solubility | insoluble | | Merck | 14,5837 | | BRN | 1902293 | | Henry's Law Constant | 6.6×10-1 mol/(m3Pa) at 25℃, HSDB (2015) | | Dielectric constant | 3.2（Ambient） | | Stability: | Stable. | | Major Application | flavors and fragrances | | Cosmetics Ingredients Functions | DENATURANT
REFRESHING
SOOTHING
FRAGRANCE | | InChI | 1S/C10H20O/c1-7(2)9-5-4-8(3)6-10(9)11/h7-11H,4-6H2,1-3H3/t8-,9+,10-/m1/s1 | | InChIKey | NOOLISFMXDJSKH-KXUCPTDWSA-N | | SMILES | CC(C)[C@@H]1CC[C@@H](C)C[C@H]1O | | LogP | 3.15 at 25℃ | | CAS DataBase Reference | 2216-51-5(CAS DataBase Reference) | | NIST Chemistry Reference | Cyclohexanol, 5-methyl-2-(1-methylethyl)-, [1R-(1«alpha»,2«beta»,5«alpha»)]-(2216-51-5) | | EPA Substance Registry System | Levomenthol (2216-51-5) |
| Hazard Codes | Xi | | Risk Statements | 37/38-41-36/37/38 | | Safety Statements | 26-39-37/39-36 | | WGK Germany | 2 | | RTECS | OT0700000 | | TSCA | TSCA listed | | HS Code | 29061100 | | Storage Class | 11 - Combustible Solids | | Hazard Classifications | Eye Irrit. 2
Skin Irrit. 2 | | Hazardous Substances Data | 2216-51-5(Hazardous Substances Data) | | Toxicity | LD50 orally in Rabbit: 3300 mg/kg LD50 dermal Rabbit > 5000 mg/kg |
| | L-Menthol Usage And Synthesis |
| Chemical Properties | white to light yellow crystal powde | | Uses | (1R,2S,5R)-(-)-Menthol (L-Menthol) is the natural form of Menthol. L-Menthol is used as: refreshing agent, food flavor,
cool and antipruritic drug, carminative drug. Menthol crystals is used for pers
onal care and cosmetics. | | Uses | L-Menthol is used as a cooling agent that strongly activates TRPM8.(Transient Receptor Potential Cation Channel, Subfamily M, Member 8 is a Protein Coding gene). It is used as analgesic (topical), antipruritic agent. It is used as: refreshing agent, food flavor, cool and antipruritic drug, carminative drug. Menthol crystals is used for pers onal care and cosmetics. | | Definition | ChEBI: A p-menthan-3-ol which has (1R,2S,5R)-stereochemistry. It is the most common naturally occurring enantiomer. | | Acquired resistance | (1R,2S,5R)-(-)-Menthol (L-Menthol) is the natural form of Menthol. L- and D-menthol are variants of the same molecule, but have a mirror-image structure in relation to each other, like the right and left hand. | | General Description | Produced and qualified by HWI pharma services GmbH.
Exact content by quantitative NMR can be found on the certificate. | | Flammability and Explosibility | Non flammable | | Biological Activity | l-Menthol inhibite the binding of 13 ligands (calcium channels, sodium channels, γ-aminobutyric acid type A (GABAA) receptor, GABA transporter, dopamine transporter, dopamine D4 receptor, adenosine A2a receptor, α2A-adrenergic receptor, histamine H2 receptor, bombesin receptor, angiotensin AT1 receptor, vasopressin V2 receptor, and leukotriene B4 receptor) with relatively high inhibition rates and acts on these ligands over a similar concentration range. It acts as a positive allosteric modulator of the GABAA receptor rather than an agonist. In periaqueductal grey neurons in rat midbrain slices, l-menthol was shown to prolong spontaneous GABAA receptor–mediated inhibitory current, most likely via a mechanism distinct from that of benzodiazepines. It acts on the dopamine D4 receptor and the dopamine transporter. l-menthol inhibits the [3H]-WIN35,428 binding, similar to GBR12909, suggesting that l-menthol inhibits the binding of dopamine to the dopamine transporter and leading to decreased dopamine uptake[1].
| | Biochem/physiol Actions | Taste at 25 ppm | | Safety Profile | Poison by intravenous
route. Moderately toxic by ingestion,
intraperitoneal, and subcutaneous routes. An
eye irritant. Mutation data reported. When
heated to decomposition it emits acrid
smoke and irritating fumes. | | Purification Methods | Crystallise menthol from CHCl3,pet ether or EtOH/water. [Barrow & Atkinson J Chem Soc 638 1939, Beilstein 6 III 133, 6 IV 150.] | | References | [1] Umezu T, et al. Identification of novel target molecules of l-menthol. Heliyon, 2021; 7: e07329. |
| | L-Menthol Preparation Products And Raw materials |
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