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| | 3-(Dimethylamino)-1-phenyl-2-propen-1-one Basic information |
| Product Name: | 3-(Dimethylamino)-1-phenyl-2-propen-1-one | | Synonyms: | 3-(Dimethylamino)acrylophenone;3-(N,N-Dimethylamino)-1-phenyl-2-propen-1-one;(2E)-3-(Dimethylamino)-1-phenylprop-2-en-1-one;3-Dimethylamino-1-phenylpropenone;NSC 601833;2-Propen-1-one, 3-(dimethylamino)-1-phenyl-;3-(Dimethylamino)phenylpropenone;3 - (dimethylamino) - 1 - (2-phenyl) - 2-propene-1-one | | CAS: | 1201-93-0 | | MF: | C11H13NO | | MW: | 175.23 | | EINECS: | | | Product Categories: | | | Mol File: | 1201-93-0.mol |  |
| | 3-(Dimethylamino)-1-phenyl-2-propen-1-one Chemical Properties |
| Melting point | 91-93°C | | Boiling point | 260.0±32.0 °C(Predicted) | | density | 1.022±0.06 g/cm3(Predicted) | | storage temp. | Sealed in dry,Room Temperature | | solubility | soluble in Methanol | | form | powder to crystal | | pka | 6.63±0.70(Predicted) | | color | White to Yellow to Green | | λmax | 325nm(lit.) |
| Hazard Codes | Xi | | HazardClass | IRRITANT | | HS Code | 2922390090 |
| | 3-(Dimethylamino)-1-phenyl-2-propen-1-one Usage And Synthesis |
| Definition | ChEBI: 3-(dimethylamino)-1-phenylprop-2-en-1-one is a carbonyl compound. | | Synthesis Reference(s) | Chemistry Letters, 13, p. 1419, 1984
The Journal of Organic Chemistry, 45, p. 4522, 1980 DOI: 10.1021/jo01310a058 | | Synthesis | In a 100 mL dry round-bottomed flask, acetophenone (1.08 g, 9 mmol) and N,N-dimethylformamide dimethyl acetal (3.9 mL, 30 mmol) were added with 30 mL of xylene as solvent. The reaction mixture was refluxed at 140 °C for 12 hours. The progress of the reaction was monitored by thin layer chromatography (TLC) and the heating was stopped after confirming the completion of the reaction. The solvent was removed by distillation under reduced pressure and the resulting crude product was purified by fast column chromatography to afford 3-(dimethylamino)-1-phenyl-2-propen-1-one (1.48 g, 97% yield) as a light yellow solid. | | References | [1] RSC Advances, 2017, vol. 7, # 45, p. 28483 - 28488
[2] Patent: CN108383763, 2018, A. Location in patent: Paragraph 0044; 0046
[3] Patent: US2011/195993, 2011, A1. Location in patent: Page/Page column 10; 14
[4] Journal of Organic Chemistry, 1980, vol. 45, # 24, p. 4857 - 4860
[5] Bioorganic and Medicinal Chemistry Letters, 2011, vol. 21, # 4, p. 1214 - 1217 |
| | 3-(Dimethylamino)-1-phenyl-2-propen-1-one Preparation Products And Raw materials |
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