KH176) manufacturers
- Sonlicromanol
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- $2500.00
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2026-06-04
- CAS:1541170-75-5
- Purity:
- Supply Ability: 10g
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| Product Name: | KH176) | | Synonyms: | KH-176
(Sonlicromanol;KH176);2H-1-Benzopyran-2-carboxamide, 3,4-dihydro-6-hydroxy-2,5,7,8-tetramethyl-N-(3R)-3-piperidinyl-, (2S)-;Sonlicromanol | | CAS: | 1541170-75-5 | | MF: | C19H28N2O3 | | MW: | 332.44 | | EINECS: | | | Product Categories: | | | Mol File: | 1541170-75-5.mol |  |
| | KH176) Chemical Properties |
| Boiling point | 570.8±50.0 °C(Predicted) | | density | 1.18±0.1 g/cm3(Predicted) | | pka | 11.29±0.40(Predicted) | | form | Solid | | color | White to off-white |
| | KH176) Usage And Synthesis |
| Uses | Sonlicromanol (KH176) is an orally active reactive oxygen species (ROS) modulator for the study in mitochondrial disease[1][2]. | | in vivo | Sonlicromanol (KH176, 10 mg/kg, ip, twice daily) has promising, but independent and nonadditive, properties for the pharmacological treatment of CI-deficiency-related mitochondrial diseases[3]. | Animal Model: | Ndufs4/ mice[3]. | | Dosage: | 10 mg/kg. | | Administration: | Twice daily by intraperitoneal injection. | | Result: | Increased lifespan of Ndufs4/ mice similar as KH176 and Clofibrate single treatment. |
| | References | [1] X Jiang, et al. Mechanism of action and potential applications of selective inhibition of microsomal prostaglandin E synthase-1-mediated PGE 2 biosynthesis by sonlicromanol's metabolite KH176m. Sci Rep. 2021 Jan 13;11(1):880. DOI:10.1038/s41598-020-79466-w
[2] Zikai Feng, et al. Comparative In Vitro Toxicology of Novel Cytoprotective Short-Chain Naphthoquinones. Pharmaceuticals (Basel). 2020 Aug 7;13(8):184. DOI:10.3390/ph13080184
[3] Sanne J C M Frambach, et al. Effects of clofibrate and KH176 on life span and motor function in mitochondrial complex I-deficient mice. Biochim Biophys Acta Mol Basis Dis. 2020 Jun 1;1866(6):165727. DOI:10.1016/j.bbadis.2020.165727 |
| | KH176) Preparation Products And Raw materials |
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