A1874 manufacturers
- A1874
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2026-07-17
- CAS:2064292-12-0
- Min. Order: 1KG
- Purity: 98%
- Supply Ability: 1000kg
- A1874
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- $50.00
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2026-07-15
- CAS:2064292-12-0
- Purity: 99.52%
- Supply Ability: 10g
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| Product Name: | A1874 | | Synonyms: | A1874;A-1874;A 1874;(6S)-N-[1-[4-[[[(2R,3S,4R,5S)-3-(3-chloro-2-fluorophenyl)-4-(4-chloro-2-fluorophenyl)-4-cyano-5-(2,2-dimethylpropyl)-2-pyrrolidinyl]carbonyl]amino]-3-methoxyphenyl]-1-oxo-5,8,11-trioxa-2-azatridec-13-yl]-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-Thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetamide;6H-Thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetamide, N-[1-[4-[[[(2R,3S,4R,5S)-3-(3-chloro-2-fluorophenyl)-4-(4-chloro-2-fluorophenyl)-4-cyano-5-(2,2-dimethylpropyl)-2-pyrrolidinyl]carbonyl]amino]-3-methoxyphenyl]-1-oxo-5,8,11-trioxa-2-azatridec-13-yl]-4-(4-chlorophenyl)-2,3,9-trimethyl-...;(2R,3S,4R,5S)-3-(3-Chloro-2-fluorophenyl)-4-(4-chloro-2-fluorophenyl)-N-[4-[2-[2-[2-[2-[[2-[(9S)-7-(4-chlorophenyl)-4,5,13-trimethyl-3-thia-1,8,11,12-tetrazatricyclo[8.3.0.02,6]trideca-2(6),4,7,10,12-pentaen-9-yl]acetyl]amino]ethoxy]ethoxy]ethoxy]ethylcarbamoyl]-2-methoxyphenyl]-4-cyano-5-(2,2-dimethylpropyl)pyrrolidine-2-carboxamide;(2R,3S,4R,5S)-3-(3-Chloro-2-fluorophenyl)-4-(4-chloro-2-fluorophenyl)-N-(4-((1-((S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-2-oxo-6,9,12-trioxa-3-azatetradecan-14-yl)carbamoyl)-2-methoxyphenyl)-4-cyano-5-neopentylpyrrolidine-2-carboxamide;Inhibitor,PROTACs,Epigenetic Reader Domain,A-1874,inhibit,A1874,A 1874;A1874 ，S8785 | | CAS: | 2064292-12-0 | | MF: | C58H62Cl3F2N9O7S | | MW: | 1173.59 | | EINECS: | | | Product Categories: | | | Mol File: | 2064292-12-0.mol |  |
| | A1874 Chemical Properties |
| density | 1.389±0.14 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | | storage temp. | Store at -20°C | | solubility | DMSO:125.0(Max Conc. mg/mL);106.51(Max Conc. mM)
Ethanol:100.0(Max Conc. mg/mL);85.21(Max Conc. mM) | | form | Solid | | pka | 13.148±0.70(predicted) | | color | White to off-white |
| | A1874 Usage And Synthesis |
| Uses | A1874 is a nutlin-based (MDM2 ligand) and BRD4-degrading PROTAC with a DC50 of 32 nM (induce BRD4 degradation in cells). Effective in inhibiting many cancer cell lines proliferation[1]. | | IC 50 | BRD4 | | References | [1] Hines J, et al. MDM2-Recruiting PROTAC Offers Superior, Synergistic Antiproliferative Activity via Simultaneous Degradation of BRD4 and Stabilization of p53. Cancer Res. 2019 Jan 1;79(1):251-262. DOI:10.1158/0008-5472.CAN-18-2918 |
| | A1874 Preparation Products And Raw materials |
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