[NPHE1]NOCICEPTIN(1-13)NH2

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Products Intro: Product Name:Nphe1]Nociceptin(1-13)NH2
CAS:267234-08-2
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Products Intro: Product Name:[NPHE1]NOCICEPTIN(1-13)NH2
CAS:267234-08-2
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Products Intro: Product Name:[Nphe1]Nociceptin(1-13)NH2
CAS:267234-08-2
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Products Intro: Product Name:[Nphe1]Nociceptin(1-13)NH2 TFA
CAS:267234-08-2
Purity:98% Package:$172.9/1mg;$567.9/5mg;$790.9/10mg;$1374.9/25mg;$1923.9/50mg;$2692.9/100mg;Bulk p Remarks:98%
[NPHE1]NOCICEPTIN(1-13)NH2 Basic information
Product Name:[NPHE1]NOCICEPTIN(1-13)NH2
Synonyms:N-(Bzl)Gly-Gly-Gly-Phe-Thr-Gly-Ala-Arg-Lys-Ser-Ala-Arg-Lys-NH2 (N-(Bzl)GlyN-Benzylglycine);N-(BZL)GLY-GLY-GLY-PHE-THR-GLY-ALA-ARG-LYS-SER-ALA-ARG-LYS-NH2;[NPHE1]NOCICEPTIN(1-13)NH2;[N-PHE1]-NOCICEPTIN FRAGMENT 1-13 AMIDE;L-Lysinamide, N-(phenylmethyl)glycylglycylglycyl-L-phenylalanyl-L-threonylglycyl-L-alanyl-L-arginyl-L-lysyl-L-seryl-L-alanyl-L-arginyl-;Bzl-GGGFTGARKSARK-NH2;N-(BN)Gly-Gly-Gly-Phe-Thr-Gly-Ala-Arg--Lys-Ser-Ala-Arg--Lys-NH2
CAS:267234-08-2
MF:C61H100N22O15
MW:1381.59
EINECS:
Product Categories:Neuropeptides;Opioid Peptides;Other Opioid Peptides;Other Opioid PeptidesPeptides for Cell Biology;Opioid receptor and opioid-like receptor
Mol File:267234-08-2.mol
[NPHE1]NOCICEPTIN(1-13)NH2 Structure
[NPHE1]NOCICEPTIN(1-13)NH2 Chemical Properties
density 1.44±0.1 g/cm3(Predicted)
storage temp. −20°C
solubility Soluble to 1 mg/ml in 10% acetonitrile
form lyophilized powder
pka12.91±0.46(Predicted)
Safety Information
WGK Germany 3
MSDS Information
ProviderLanguage
SigmaAldrich English
[NPHE1]NOCICEPTIN(1-13)NH2 Usage And Synthesis
Uses[Nphe1]Nociceptin(1-13)NH2, a novel nociceptin/orphanin FQ (NC) endogenous ligand, is a selective and competitive ociceptin receptor antagonist without any residual agonist activity. [Nphe1]nociceptin(1-13)NH2?binds selectively to recombinant nociceptin receptors (pKi=8.4) and antagonizes the inhibitory effects of nociceptin on cyclic AMP accumulation in CHO cells (pA2=6.0). [Nphe1]Nociceptin(1-13)NH2 has the potential to act as an analgesic agent[1].
References[1] Y Hashimoto, et al. Antagonistic effects of [Nphe1]nociceptin(1-13)NH2 on nociceptin receptor mediated inhibition of cAMP formation in Chinese hamster ovary cells stably expressing the recombinant human nociceptin receptor DOI:10.1016/s0304-3940(99)00915-5
[2] G Calo', et al. Characterization of [Nphe(1)]nociceptin(1-13)NH(2), a new selective nociceptin receptor antagonist. Br J Pharmacol.?2000 Mar;129(6):1183-93. DOI:10.1038/sj.bjp.0703169
[NPHE1]NOCICEPTIN(1-13)NH2 Preparation Products And Raw materials
Tag:[NPHE1]NOCICEPTIN(1-13)NH2(267234-08-2) Related Product Information
H-LEU-PRO-ARG-LEU-LEU-HIS-THR-ASP-SER-ARG-MET-ALA-THR-ILE-ASP-PHE-PRO-LYS-LYS-ASP-PRO-THR-THR-SER-LEU-GLY-ARG-PRO-PHE-PHE-LEU-PHE-ARG-PRO-ARG-ASN-NH2 Cenupatide Met-enkephalinamide ELA-14 (human) GLY-SER-SER-PHE-LEU-SER-PRO-GLU-HIS-GLN-LYS-ALA-GLN-GLN-ARG-LYS-GLU-SER-LYS-LYS-PRO-PRO-ALA-LYS-LEU-GLN-PRO-ARG RRKDLHDDEEDEAMSITA GIP (HUMAN) ASN-GLU-ALA-TYR-VAL-HIS-ASP-ALA-PRO-VAL-ARG-SER-LEU-ASN UFP-101 [NPHE1]NOCICEPTIN(1-13)NH2

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