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| [NPHE1]NOCICEPTIN(1-13)NH2 Basic information |
| [NPHE1]NOCICEPTIN(1-13)NH2 Chemical Properties |
density | 1.44±0.1 g/cm3(Predicted) | storage temp. | −20°C | solubility | Soluble to 1 mg/ml in 10% acetonitrile | form | lyophilized powder | pka | 12.91±0.46(Predicted) |
| [NPHE1]NOCICEPTIN(1-13)NH2 Usage And Synthesis |
Uses | [Nphe1]Nociceptin(1-13)NH2, a novel nociceptin/orphanin FQ (NC) endogenous ligand, is a selective and competitive ociceptin receptor antagonist without any residual agonist activity. [Nphe1]nociceptin(1-13)NH2?binds selectively to recombinant nociceptin receptors (pKi=8.4) and antagonizes the inhibitory effects of nociceptin on cyclic AMP accumulation in CHO cells (pA2=6.0). [Nphe1]Nociceptin(1-13)NH2 has the potential to act as an analgesic agent[1]. | References | [1] Y Hashimoto, et al. Antagonistic effects of [Nphe1]nociceptin(1-13)NH2 on nociceptin receptor mediated inhibition of cAMP formation in Chinese hamster ovary cells stably expressing the recombinant human nociceptin receptor DOI:10.1016/s0304-3940(99)00915-5 [2] G Calo', et al. Characterization of [Nphe(1)]nociceptin(1-13)NH(2), a new selective nociceptin receptor antagonist. Br J Pharmacol.?2000 Mar;129(6):1183-93. DOI:10.1038/sj.bjp.0703169 |
| [NPHE1]NOCICEPTIN(1-13)NH2 Preparation Products And Raw materials |
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